The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond.

Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health challenge. Since the discovery of abnormal aldolase A (ALDOA) expression in liver cancer for the first time, its overexpression has been identified in numerous cancers, including colorectal cancer (CRC), breast cancer (BC), cervical adenocarcinoma (CAC), non-small cell lung cancer (NSCLC), gastric cancer (GC), hepatocellular carcinoma (HCC), pancreatic cancer adenocarcinoma (PDAC), and clear cell renal cell carcinoma (ccRCC). Moreover, ALDOA overexpression promotes cancer cell proliferation, invasion, migration, and drug resistance, and is closely related to poor prognosis of patients with cancer.

New Trauma Scoring System for Geriatric Trauma and Massive Transfusion Prediction.

Background: Early identification of massive transfusion (MT) requirement in geriatric patients with severe trauma is challenging. Existing systems for predicting MT need in trauma patients have not been systematically evaluated for their relevance to the geriatric population. This study aimed to evaluate the predictive accuracy of initial vital signs and the Glasgow coma scale (GCS) in geriatric trauma patients for predicting MT.

Using HBmito Crimson to Observe Mitochondrial Cristae Through STED Microscopy.

Mitochondrial cristae, formed by folding the mitochondrial inner membrane (IM), are essential for cellular energy supply. However, the observation of the IM is challenging due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vitro probes specifically targeting the IM. Here, we describe a detailed imaging protocol for the mitochondrial inner membrane using the Si-rhodamine dye HBmito Crimson, which has excellent photophysical properties, to label live cells for imaging via stimulated emission depletion (STED) microscopy.

Role of the Dorsal Cortex of the Inferior Colliculus in the Precedence Effect.

BACKGROUND The precedence effect (PE) is a physiological phenomenon for accurate sound localization in a reverberant environment. Physiological studies of PE have mostly focused on the central nucleus of the inferior colliculus (CNIC), which receives ascending and descending projections, as well as projections from the shell of the inferior colliculus (IC) and contralateral IC. However, the role of the dorsal cortex of the IC (DCIC), which receives ascending and descending projections to ensure sound information processing and conduction on PE formation, remains unclear.

Cockpit-Llama: Driver Intent Prediction in Intelligent Cockpit via Large Language Model.

The cockpit is evolving from passive, reactive interaction toward proactive, cognitive interaction, making precise predictions of driver intent a key factor in enhancing proactive interaction experiences. This paper introduces Cockpit-Llama, a novel language model specifically designed for predicting driver behavior intent. Cockpit-Llama predicts driver intent based on the relationship between current driver actions, historical interactions, and the states of the driver and cockpit environment, thereby supporting further proactive interaction decisions.