Morphological Study on Lenticulostriate Arteries in Patients With Middle Cerebral Artery Stenosis at 7 T MRI.

Background: Middle cerebral artery (MCA) stenosis affects lenticulostriate arteries (LSAs) that supply the basal ganglia. Increased spatial resolution and signal-to-noise ratio of 7 T could facilitate morphological imaging of very-small-diameter LSAs.

Purpose: To evaluate differences in morphological characteristics of LSA among different MCA stenoses.

Salmonella Typhimurium derived OMV nanoparticle displaying mixed heterologous O-antigens confers immunogenicity and protection against STEC infections in mice.

Shiga toxin-producing Escherichia coli (STEC) is one of the major pathogens responsible for severe foodborne infections, and the common serotypes include E. coli O157, O26, O45, O103, O111, O121, and O145. Vaccination has the potential to prevent STEC infections, but no licensed vaccines are available to provide protection against multiple STEC infections.

Pharmacokinetic/pharma-codynamic study of pralurbactam (FL058) combined with meropenem in a neutropenic murine thigh infection model.

Introduction: Pralurbactam (FL058) is a novel β-lactamase inhibitor with good inhibitory activity on class A, C, and D β-lactamases. This study aimed to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of pralurbactam/meropenem in a neutropenic murine thigh infection model.

Methods: After 2-h infection, neutropenic mice was treated with meropenem every 2 h alone or in combination with pralurbactam at different dosing frequencies for 24 h, and the colony count in the thighs was determined before and after treatment.

Strength characteristics and prediction model of solidified municipal sludge reinforced by dredged silt combined with sodium silicate and polyurethane.

The treatment and resource utilization of municipal sludge and dredged silt have been rendered urgent by the acceleration of urbanization and stricter environmental protection demands. An effective solution was developed to address the challenges of poor mechanical properties and the difficulty in directly using cement-based materials for municipal sludge treatment. The utilization of dredged silt with high water content served as the foundational skeleton material.

Distinguishing local isomorphism classes in quasicrystals by high-order harmonic spectroscopy.

Electron diffraction spectroscopy is a fundamental tool for investigating quasicrystal structures, which unveils the quasiperiodic long-range order. Nevertheless, it falls short in effectively distinguishing separate local isomorphism classes. This is a long outstanding problem.