Optimizing surgical outcomes in papillary thyroid carcinoma with Hashimoto's Thyroiditis: a retrospective comparative study of unilateral and total thyroidectomy.

The management of papillary thyroid carcinoma (PTC) concurrent with Hashimoto's thyroiditis (HT) lacks standardized guidelines, especially concerning surgical strategies. This study aimed to compare unilateral thyroidectomy (UT) with total thyroidectomy (TT) in PTC-HT patients to optimize clinical management and improve postoperative outcomes. This retrospective study included PTC-HT patients undergoing thyroid surgery at a tertiary academic medical institution from January 2018 to August 2023.

Driving mechanism of urban expansion in the Bohai Rim urban agglomeration from the perspective of spatiotemporal dynamic analysis.

The urban agglomeration represents the predominant form of new urbanisation, yet the evolution of its internal spatial structure exhibits pronounced spatial and temporal heterogeneity. This study concentrates on the Bohai Rim urban agglomeration, one of three major urban agglomerations in China, which has received comparatively limited research attention but has also undergone substantial urbanisation. Therefore, we reassessed and explored the spatial-temporal evolution of the spatial structure of urban expansion using Exploratory Spatiotemporal Data Analysis (ESTDA), and summarized the driving mechanisms using Geographically and Temporally Weighted Regression (GTWR).

Untargeted metabolite profiling reveals metabolic disorders in livers of rats with mepiquat exposure.

Mepiquat is a contaminant produced in thermal-processed food. It can induce spleen and liver injury. However, the mechanism that mepiquat induced hepatotoxicity remains unclear.

Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.

Background: The clinical characteristics of major depressive disorder (MDD) in adolescents show notable gender-related differences, but the cause of these differences is still not understood. The current research concentrates on the changes in neurometabolism and neuroendocrine function, aiming to identify differences in endocrine function and brain metabolism between male and female adolescents with MDD.

Methods: A total of 121 teenagers diagnosed with MDD (43 males and 78 females) were enlisted as participants.

Transvaginal repair of apical vesicovaginal fistula via vaginal natural orifice transluminal endoscopic surgery (V-NOTES): a modified surgical technique and its outcomes.

To report the procedure of an alternative modified transvaginal repair technique (V-NOTES) and their outcomes in apical vesicovaginal fistula. Between January 2020 and January 2023, gynecological procedures resulted in the diagnosis of apical VVFs in 26 patients, 17 of whom had undergone transvaginal repair of apical vesicovaginal fistula via vaginal V-NOTES. Those patients were contacted and followed up.