Efficacy of butylphthalide in preventing cognitive decline in ischaemic stroke survivors: a 12-month prospective following-up study.

Background: Cognitive decline is a significant concern for stroke survivors, affecting their quality of life and increasing their burden on the healthcare system. DL-3-n-butylphthalide (butylphthalide) has shown efficacy in the short-term treatment of various cognitive impairments. This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.

Enhancing the Transformer Model with a Convolutional Feature Extractor Block and Vector-Based Relative Position Embedding for Human Activity Recognition.

The Transformer model has received significant attention in Human Activity Recognition (HAR) due to its self-attention mechanism that captures long dependencies in time series. However, for Inertial Measurement Unit (IMU) sensor time-series signals, the Transformer model does not effectively utilize the a priori information of strong complex temporal correlations. Therefore, we proposed using multi-layer convolutional layers as a Convolutional Feature Extractor Block (CFEB).

Parameterization of the Differences in Neural Oscillations Recorded by Wearable Magnetoencephalography for Chinese Semantic Cognition.

Neural oscillations observed during semantic processing embody the function of brain language processing. Precise parameterization of the differences in these oscillations across various semantics from a time-frequency perspective is pivotal for elucidating the mechanisms of brain language processing. The superlet transform and cluster depth test were used to compute the time-frequency representation of oscillatory difference (ODTFR) between neural activities recorded by optically pumped magnetometer-based magnetoencephalography (OPM-MEG) during processing congruent and incongruent Chinese semantics.

Identification of a Novel Cuproptosis Inducer That Induces ER Stress and Oxidative Stress to Trigger Immunogenic Cell Death in Tumors.

Cuproptosis, a copper-dependent form of regulated cell death, has been implicated in the progression and treatment of various tumors. The copper ionophores, such as Disulfiram (DSF), an FDA-approved drug previously used to treat alcohol dependence, have been found to induce cuproptosis. However, the limited solubility and effectiveness of the combination of DSF and copper ion restrict its widespread application.

Metaproteomics reveals metabolic activities potentially involved in bloom formation and succession during a mixed dinoflagellate bloom of Prorocentrum obtusidens and Karenia mikimotoi.

Understanding metabolic activities involved in bloom formation during a single-species algal bloom has improved greatly. However, little is known about metabolic activities during a multi-species algal bloom. Here, we investigated protein expression profiles at different bloom stages of a mixed dinoflagellate bloom caused by Karenia mikimotoi and Prorocentrum obtusidens (syn.