Review of Applications of Microneedling in Melasma.

Background: Melasma, a common skin pigmentation disease, can negatively impact patients' mental health, social interactions, and physical appearance. Although we now have several treatments accessible, such as medicines, chemical peels, and phototherapy, which can help ease symptoms to some extent, the requirement for a long-term effective and safe treatment for patients is far from met. In the face of this problem, microneedling, as an innovative treatment, provides a new avenue for treating melasma.

E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production.

Aldosterone-producing adenoma (APA) is a leading cause of primary aldosteronism (PA), a condition marked by excessive aldosterone secretion. CYP11B2, the aldosterone synthase, plays a critical role in aldosterone biosynthesis and the development of APA. Despite its significance, encoding regulatory mechanisms governing CYP11B2, particularly its degradation, remain poorly understood.

Severe bongkrekic acid poisoning caused by eating spoiled Auricularia auricula: a case report.

Background: Bongkrekic acid is a rare mitochondrial toxin produced by the Burkholderia cocovenenans subsp. Bongkrekic acid poisoning has a case fatality rate of more than 50%, and progresses rapidly to multiple organ failure. However, limited clinical information is available regarding this phenomenon.

Development and validation of non-invasive prediction models for assessing kidney histopathological activity index in lupus nephritis.

Objective: To develop and validate prediction models for estimating the activity index (AI) of kidney histopathology in lupus nephritis (LN) using clinical and laboratory data.

Methods: This study used single-center data from patients with kidney biopsy-confirmed LN between January 2012 and March 2022. The development and validation datasets were temporally cut.

Efficacy and safety of dietary polyphenol administration as assessed by hormonal, glycolipid metabolism, inflammation and oxidative stress parameters in patients with PCOS: a meta-analysis and systematic review.

Background: The current knowledge about the efficacy and safety of dietary polyphenol administration in patients with polycystic ovarian syndrome (PCOS) is divergent.

Objective: To evaluate the pooled efficacy and safety of dietary polyphenol administration in the treatment of patients with PCOS.

Methods: The pubmed, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) of dietary polyphenol administration for the treatment of PCOS.