Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.

Androgen receptor (AR) splice variants, of which ARv7 is the most common, are increased in castration-resistant prostate cancer, but the extent to which they drive AR activity is unclear. We generated a subline of VCaP cells (VCaP16) that is resistant to the AR inhibitor enzalutamide (ENZ). AR activity in VCaP16 is driven by ARv7, independently of full-length AR (ARfl), and its cistrome and transcriptome mirror those of ARfl in VCaP cells.

An internally validated prognostic nomogram model predicts the stone-free rate following endoscopic combined intrarenal surgery for renal stones.

Background: Here, we aim to develop and validate a viable prognostic nomogram model for predicting a stone-free rate of kidney stones patients based on retrospective cohort analysis.

Methods: This is a retrospective study that obtained a continuous cohort from the databases of two hospitals (General Hospital of Southern Theater Command, and Guangdong Second Provincial General Hospital), including 522 patients with kidney stones who underwent Endoscopic Combined Intrarenal Surgery (ECIRS) from January 2015 to December 2022.The characteristics of the primary cohort between the SF (stone-free) and SR (stone residue) groups were identified using single factor and multivariate logistic regression analyses.

Utilizing heterogeneity of lignin to diminish supercooling of phase change material nano-capsules with high latent heat.

Fatty acids, in particular, are valued as phase change materials (PCMs) for their non-toxic, biodegradable nature and thermal stability. However, the leakage and supercooling issues during phase transitions limit their application. Microencapsulation of PCMs, while improving thermal response, often leads to supercooling, complicating temperature regulation and increasing energy consumption.

Effect of lignin carbon material on phosphorus solubilisation performance of Bacillus megaterium.

Secondary salinisation significantly compromises soil quality because of the over-application of chemical fertilisers. The combined application of biochar and microorganisms enhanced soil physicochemical properties and improved soil remediation efficiency. However, different types of biochar had varying effects on microbial growth and reproduction.

Identification and function analysis of Toll-like receptor 4 (TLR4) from Manila clam (Ruditapes philippinarum).

Toll-like receptor 4 (TLR4) is a pattern recognition receptor that activates innate immunity in response to pathogen infection. However, the role of TLR4 in pathogen-induced apoptosis and host immunity in mollusks remains largely unknown. In this study, the TLR4 of the Manila clam Ruditapes philippinarum (RpTLR4) was cloned.