Publications by authors named "X Iturrioz"
Background: To protect patients after myocardial infarction (MI) and preserve cardiac function, the development of new therapeutics remains an important issue. Apelin, a neuro-vasoactive peptide, increases aqueous diuresis and cardiac contractility while reducing vascular resistance. However, its in vivo half-life is very short.
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- Researchers have developed a new fluorescent unnatural amino acid called Alared, designed for environmental sensitivity and efficient operation in the red part of the light spectrum.
- Alared can be incorporated into bioactive peptides and exhibits varying fluorescence properties based on its surrounding environment, making it useful for studying biomolecular interactions.
- The ability to track Alared-labeled peptides in live cells with minimal interference allows for better understanding of receptor activation and peptide binding behavior in cellular contexts.
Article Synopsis
- The renin-angiotensin system (RAS) is crucial for regulating heart and blood vessel functions, involving key components like ACE and the AT1 and AT2 receptors.
- While ACE and AT1 are targets for hypertension treatments, the AT2 receptor's role remains less understood and underutilized.
- Researchers discovered a new toxin called A-CTX-cMila from Brazilian viper venom, showing strong selectivity for the AT1 receptor and blocking various cellular pathways, marking it as the first animal toxin known to impact angiotensin II receptors.
Herein, we describe a catalyst-free thia-Diels-Alder cycloaddition for the chemoselective labeling of fully deprotected phosphonodithioester-peptides in solution with fluorophores functionalized with an exocyclic diene. The reaction was optimized on the model tripeptide containing a lysine residue, which enabled its rapid and straightforward labeling with three different fluorophores (fluorescein, lissamine rhodamine B, and squaraine) in very mild conditions (HO/PrOH, 37 °C, 1 h). The reaction was then successfully applied to the chemoselective labeling of fully deprotected apelin-13 with squaraine dye.
View Article and Find Full Text PDFHigh blood pressure and consequential cardiovascular diseases are among the top causes of death worldwide. The apelinergic (APJ) system has emerged as a promising target for the treatment of cardiovascular issues, especially prevention of ischemia reperfusion (IR) injury after a heart attack or stroke. However, rapid degradation of the endogenous apelin peptides limits their use as therapeutic agents.
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