Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis.

Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infections that is initiated by the body's innate immune system. Nearly a decade ago, we discovered that bacterial lipopolysaccharide (LPS) and serum amyloid A (SAA) upregulated Connexin 43 (Cx43) and Pannexin 1 (Panx1) hemichannels in macrophages. When overexpressed, these hemichannels contribute to sepsis pathogenesis by promoting ATP efflux, which intensifies the double-stranded RNA-activated protein kinase R (PKR)-dependent inflammasome activation, pyroptosis, and the release of pathogenic damage-associated molecular pattern (DAMP) molecules, such as HMGB1.

Enhanced physicochemical properties of chitosan films with generation of kafirin particles: optimization response surface methodology.

Biodegradable food packaging has gained significant attention owing to environmental concerns. Chitosan (CS), a natural polysaccharide, is popular in packaging films, however, its high hydrophilicity, brittleness, and low mechanical strength limit its use. To improve CS film performance, kafirin (Kaf), glycerol (GE), and tannic acid (TA) were added to create biocomposite films.

Spanning three decades: global research wave and future prospects of broader autism phenotype-a visual researches by CiteSpace and VOS viewer.

Objectives: To conduct a comprehensive review of the literature pertaining to the broader autism phenotype, the paper endeavors to delineate the key research directions and topics, document the current research trends, and furnish insightful analyses and novel perspectives to foster future advancements in the field, with the aid of CiteSpace and VOS viewer.

Methods: CiteSpace and VOS viewer are two kinds of software for visualizing citations that is intended to examine academic literature and identify possible sources of knowledge. The Web of Science Core Collection database was used to retrieve articles from 1994 to 2024 that discussed the autism phenotype in general.

Development of targeted safety hazard management plans utilizing multidimensional association rule mining.

Investigating hidden hazards and implementing closed-loop management are essential strategies for accident prevention in the mining industry. This study tackles a key challenge in applying association rule mining to the development of hazard management plans for underground mines. The current approach mainly focuses on hazard description data, often underutilizing critical information such as hazard time and location.

A Model for Decoding Resistance in Precision Oncology: Acquired Resistance to FGFR inhibitors in Cholangiocarcinoma.

Background: Fibroblast growth factor receptor (FGFR) inhibitors have significantly improved outcomes for patients with FGFR-altered cholangiocarcinoma, leading to their regulatory approval in multiple countries. However, as with many targeted therapies, acquired resistance limits their efficacy. A comprehensive, multimodal approach is crucial to characterizing resistance patterns to FGFR inhibitors.