Chemoenzymatic Synthesis of Core-Fucosylated Asymmetrical N-Glycans with Different-Length Oligo-N-Acetyllactosamine Motifs and Their Sialylated Extensions.

An efficient chemoenzymatic approach for the diversity-oriented synthesis of core-fucosylated asymmetrical N-glycans bearing different lengths of oligo-N-acetyllactosamine (LacNAc) and their sialylated extensions was described. Two oligosaccharide precursors were chemically synthesized by length-controlled introduction of oligo-LacNAc motifs through stereoselectively iterative glycosylation of a common hexasaccharide intermediate. Both oligosaccharide precursors can be well recognized by α1,6-fucosyltransferase FUT8 to generate core-fucosylated N-glycans, which was subjected to divergent enzymatic extension using a galactosyltransferase module and two sialyltransferase modules to provide a wide array of core-fucosylated asymmetrical biantennary N-glycans having different-length oligo-LacNAc motifs capped by various sialic acid-linkages.

CT-based radiomics-deep learning model predicts occult lymph node metastasis in early-stage lung adenocarcinoma patients: A multicenter study.

Objective: The neglect of occult lymph nodes metastasis (OLNM) is one of the pivotal causes of early non-small cell lung cancer (NSCLC) recurrence after local treatments such as stereotactic body radiotherapy (SBRT) or surgery. This study aimed to develop and validate a computed tomography (CT)-based radiomics and deep learning (DL) fusion model for predicting non-invasive OLNM.

Methods: Patients with radiologically node-negative lung adenocarcinoma from two centers were retrospectively analyzed.

Progress and Perspectives in 2D Piezoelectric Materials for Piezotronics and Piezo-Phototronics.

The emergence of two-dimensional (2D) materials has catalyzed significant advancements in the fields of piezotronics and piezo-phototronics, owing to their exceptional mechanical, electronic, and optical properties. This review provides a comprehensive examination of key 2D piezoelectric and piezo-phototronic materials, including transition metal dichalcogenides, hexagonal boron nitride (h-BN), and phosphorene, with an emphasis on their unique advantages and recent research progress. The underlying principles of piezotronics and piezo-phototronics in 2D materials is discussed, focusing on the fundamental mechanisms which enable these phenomena.

Predicting PD-L1 in Lung Adenocarcinoma Using F-FDG PET/CT Radiomic Features.

: This study aims to retrospectively analyze the clinical and imaging data of 101 patients with lung adenocarcinoma who underwent [F]FDG PET/CT examination and were pathologically confirmed in the Department of Nuclear Medicine at Peking University Cancer Hospital. This study explores the predictive value and important features of [F]FDG PET/CT radiomics for PD-L1 expression levels in lung adenocarcinoma patients, assisting in screening patients who may benefit from immunotherapy. : 101 patients with histologically confirmed lung adenocarcinoma who received pre-treatment [F] FDG PET/CT were included.

Reply to Okura et al. Comment on "Pu et al. Predicting Postoperative Lung Cancer Recurrence and Survival Using Cox Proportional Hazards Regression and Machine Learning. 2025, , 33".

Thank you for your thoughtful and constructive comments on our study [...