Publications by authors named "X Guillonneau"
Article Synopsis
- - Primary open-angle glaucoma (POAG) is a major cause of vision loss linked to high intraocular pressure (IOP), with the trabecular meshwork (TM) being essential for regulating IOP by filtering aqueous humor.
- - The study investigates the effects of the TGF-β2 signaling pathway on TM dysfunction using human TM explants, revealing changes in gene expression associated with extracellular matrix regulation and fibrotic signaling through bulk RNA sequencing.
- - Findings highlight TGF-β2's impact on molecular pathways, including BMP and Wnt signaling, which may provide insights for developing treatments targeting these mechanisms to prevent TM dysfunction in glaucoma.
Article Synopsis
- * Parkinson's disease (PD) patients treated with l-DOPA show some protection against nAMD, but the exact mechanism was unclear until now.
- * Research indicates that l-DOPA enhances dopamine receptor D2 (DRD2) signaling, which may inhibit the harmful growth of blood vessels in the eye, suggesting that DRD2 agonists could be potential complementary treatments for nAMD.
Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial cells but also of monocyte-derived cells, which promote photoreceptor degeneration and choroidal neovascularization. Infiltrating blood monocytes can originate directly from bone marrow, but also from a splenic reservoir, where bone marrow monocytes develop into angiotensin II receptor (ATR1) splenic monocytes.
View Article and Find Full Text PDFRodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals.
Cold Spring Harb Perspect Med
October 2024
Rodent models of retinal degeneration are essential for the development of therapeutic strategies. In addition to living animal models, we here also discuss models based on rodent cell cultures, such as purified retinal ganglion cells and retinal explants. These ex vivo models extend the possibilities for investigating pathological mechanisms and assessing the neuroprotective effect of pharmacological agents by eliminating questions on drug pharmacokinetics and bioavailability.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM), characterized by hyperglycemia and dyslipidemia, leads to nonproliferative diabetic retinopathy (NPDR). NPDR is associated with blood-retina barrier disruption, plasma exudates, microvascular degeneration, elevated inflammatory cytokine levels, and monocyte (Mo) infiltration. Whether and how the diabetes-associated changes in plasma lipid and carbohydrate levels modify Mo differentiation remains unknown.
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