Publications by authors named "X Girerd"
Objective: The role of treatment with renin-angiotensin-aldosterone system blockers at the onset of COVID-19 infection is not known in the geriatric population. The aim of this study was to assess the relationship between angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitor (ACEI) use and in-hospital mortality in geriatric patients hospitalized for COVID-19.
Design: This observational retrospective study was conducted in a French geriatric department.
In France, 1 adult out of 3 is affected by hypertension and only 1 hypertensive out of 4 achieves blood pressure targets (<140/90mmHg). This proportion is significantly better in similar countries (e.g.
View Article and Find Full Text PDFArticle Synopsis
- Gain-of-function mutations in the WNK1 and WNK4 genes cause familial hyperkalemic hypertension (FHHt), which leads to high blood pressure and elevated potassium levels along with metabolic acidosis.
- Recent research has identified new mutations in the WNK1 gene that affect its interaction with the KLHL3-CUL3 ubiquitin ligase complex, crucial for renal ion transport regulation.
- Functional studies and a CRISPR/Cas9 mouse model demonstrated that these mutations result in diminished ubiquitination of the kidney-specific KS-WNK1 isoform, leading to increased activation of renal ion transport pathways and altered potassium balance.