A novel interplay between bacteria and metabolites in different early-stage lung cancer: an integrated microbiome and metabolome analysis.

Background: The carcinogenesis mechanism of early-stage lung cancer (ESLC) remains unclear. Microbial dysbiosis is closely related to tumor development. This study aimed to analyze the relationship between microbiota dysbiosis in ESLC.

Techniques and analytic workflow for spatial transcriptomics and its application to allergy and inflammation.

Spatial profiling, through single-cell gene level expression data paired with cell localization, offers unprecedented biological insights within the intact spatial context of cells in healthy and diseased tissue, adding a novel dimension to data interpretation. This review summarizes recent developments in this field, its application to allergy and inflammation, and recent single-cell resolution platforms designed for spatial transcriptomics with a focus on data processing and analyses for efficient biological interpretation of data. By preserving spatial context, these technologies provide critical insights into tissue architecture and cellular interactions unattainable with traditional transcriptomics methods, such as revealing localized inflammatory cell network in atopic dermatitis, and T-cell interactions in the lung in chronic obstructive pulmonary disease.

The window of opportunity: Estimating the role of climate finance on urban-rural electricity inequality.

Access to electricity is vital for enhancing human welfare; however, it is not equally distributed between rural and urban demographics. This paper, for the first time, examine the impact of climate finance on electricity accessibility, and the inequality of electricity accessibility between urban and rural areas. Based on the dataset covering 125 countries during 2002-2020, and by using the instrumental Variables-Generalized Method of Moments model, we mainly arrive at the following conclusions.

mTORC1 regulates the proliferation of SOX9 porcine skin-derived stem cells (pSDSCs) by promoting S6K phosphorylation.

Skin-derived stem cells (SDSCs) are a subtype of adult stem cells (ASCs) that are widely harvested and exempt from ethical restrictions in clinical applications. These cells possess capabilities for self-renewal, proliferation, and multi-lineage differentiation. Compared to model animals like rats and mice, pigs exhibit greater physiological similarity to humans.

Room-temperature phosphorescent transparent wood.

Transparent wood with high transmittance and versatility has attracted great attention as an energy-saving building material. Many studies have focused on luminescent transparent wood, while the research on organic afterglow transparent wood is an interesting combination. Here, we use luminescent difluoroboron β-diketonate (BFbdk) compounds, methyl methacrylate (MMA), delignified wood, and initiators to prepare room-temperature phosphorescent transparent wood by thermal initiation polymerization.