Publications by authors named "X F Walboomers"

Graphene-based materials (GBMs) hold strong promise to restore the spinal cord microenvironment and promote functional recovery after spinal cord injury (SCI). Nanocomposites consisting of reduced graphene oxide (rGO) and adipose tissue-derived extracellular matrix (adECM) are known to promote neuronal growth in vitro and to evoke a biocompatible response in vivo when implanted on top of the intact spinal cord. In this study, pristine adECM and adECM-rGO nanocomposites are implanted directly after hemisection SCI in rats.

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Background: Tooth wear is the loss of dental hard tissue due to chemical and mechanical processes, and its prevalence ranges from 13 to 80 % in the general population. Management depends on understanding potential risk factors; however, the role of saliva as one of them is not completely understood. The aim of this study was to explore the relationship between salivary pH and flow, and tooth wear in patients referred to a specialized dental clinic for tooth wear management.

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Article Synopsis
  • - Emerging research highlights that osteoclasts (OCs) have important roles in both bone formation and regeneration, beyond their traditional function of bone resorption, but their lifecycle and characteristics are still not fully understood.
  • - Osteoclasts originate from osteoclast precursors (OCPs) derived from erythromyeloid progenitors (EMPs) during embryonic development and shift to being primarily sourced from hematopoietic stem cells (HSCs) postnatally, with their absence leading to serious bone structure issues.
  • - The paper also discusses the challenges in isolating pure OC cultures and understanding their in vivo functions, as they interact closely with the immune system and blood vessels, and it offers insights into OCP
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Treating bone infections with common antibiotics is challenging, since pathogens like can reside inside macrophages. To target these intracellular bacteria, we have proposed nanoparticles (NPs) as drug carriers. This study aims to investigate the efficacy of hydroxyapatite and gelatin NPs, selected in view of their bone mimicry and potential for targeted delivery, as carriers for the antibacterial agents zinc and vancomycin.

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Despite the immense need for effective treatment of spinal cord injury (SCI), no successful repair strategy has yet been clinically implemented. Multifunctional biomaterials, based on porcine adipose tissue-derived extracellular matrix (adECM) and reduced graphene oxide (rGO), were recently shown to stimulate neural stem cell growth and differentiation. Nevertheless, their functional performance in clinically more relevant conditions remains largely unknown.

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