Long-term protective efficacy of the produced HPV-16/18 bivalent human papillomavirus vaccine in women vaccinated at 18-45 years: A 9-year follow-up study.

Background: To assess the enduring protective efficacy of the recombinant human papilloma virus (HPV) 16/18 bivalent vaccine (produced in ) in preventing HPV infection.

Methods: A long-term follow-up study was conducted in Xinmi, Henan Province, in September 2022, 9 years post-administration of the initial vaccine dose. This study was grounded in the phase III clinical trial of the vaccine (NCT01735006).

Bioinspired gel polymer electrolyte for wide temperature lithium metal battery.

Stable operation of Li metal batteries with gel polymer electrolytes in a wide temperature range is highly expected. However, insufficient dynamics of ion transport and unstable electrolyte-electrode interfaces at extreme temperatures greatly hinder their practical applications. We report a bioinspired gel polymer electrolyte that enables high-energy-density Li metal batteries to work stably in a wide temperature range from -30 to 80 °C.

Correction: Neuroprotective effect of Kaempferol Glycosides against brain injury and Neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.

[This corrects the article DOI: 10.1371/journal.pone.

Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.

Tumors undergo metabolic reprogramming to meet the energetic, synthetic and redox demands essential for malignancy, often characterized by increased glycolysis and lactate production. However, the role of mitochondrial metabolism in tumor immunity remains unclear. The present study integrates spatial transcriptomics, bulk transcriptomics and proteomics, revealing a strong link between the metabolite succinyl-CoA and tumor immunity as well as the efficacy of anti-programmed cell death protein-1 (PD-1) therapy in patients with melanoma.

Impact of Spatial Interactions in Polycarbonate-Based Electrolytes on Ion Transport Dynamics and Battery Performance.

Polymer electrolytes (PEs) show great promise in next-generation solid-state batteries. The interactions between functional monomers and lithium salts in PEs remain ambiguous, constraining the material design strategy aimed at optimizing the electrochemical performance. Here, we report on the local spatial interactions among the components in polycarbonate-based electrolytes, as determined through nuclear magnetic resonance (NMR) techniques.