PANoptosis-related gene biomarkers in aortic dissection.

Introduction: Programmed cell death of vascular smooth muscle cells (VSMCs) is critical in the pathogenesis of aortic dissection (AD), yet the role of PANoptosis-comprising pyroptosis, apoptosis, and necroptosis-remains unclear.

Methods: We utilized the GSE213740 single-cell sequencing dataset to assess PANoptosis levels in VSMCs. Datasets GSE153434 and GSE147026 were employed to identify differentially expressed genes (DEGs) and perform weighted gene co-expression network analysis.

An Examination of Internet Use and Its Association With Gender Ideology Among Older Adults: Insights From China.

Internet use among older Chinese adults is widespread, but little is known about the correlation between internet use and the evolution of gender ideology among this demographic. Using nationally representative data from the 2017 Chinese General Social Survey (CGSS), we found that young-old Chinese women aged 60-69 who are frequent internet users demonstrate a markedly elevated level of egalitarian gender ideology compared to those who use the internet less frequently. The length of online reading serves as a mediating factor that connects these two aspects.

An Overview of Predictive Biomarkers and Detection Approaches for Immunotherapy Response in GI Malignancies.

This review provides an in-depth exploration of the evolving role of immunotherapy in gastrointestinal (GI) cancers, with a particular focus on immune checkpoint inhibitors (ICIs) and their associated predictive biomarkers. We present a detailed analysis of established biomarkers, such as PD-L1, microsatellite instability (MSI), tumor mutational burden (TMB), and the tumor microenvironment (TME), as well as emerging biomarkers, including gut microbiota and Epstein-Barr virus (EBV). The predictive value of these biomarkers in guiding clinical decision-making and optimizing immunotherapy outcomes is thoroughly discussed.

Psychometric properties of the Chinese version of the Quiet Quitting Scale.

Background: The phenomenon of quiet quitting has attracted considerable attention within the nursing community. Elevated quiet quitting levels can weaken the work environment, reducing healthcare efficiency and quality. However, appropriate assessment tools to measure this phenomenon remain unavailable in China.