Publications by authors named "X Delavenne"
Background: Methotrexate (MTX) is the first-line treatment for Rheumatoid Arthritis (RA), yet 30%-50% of RA patients develop resistance to MTX, which can manifest several years after treatment initiation.
Objective: This study investigates the relationship between erythrocyte methotrexate polyglutamates (MTX-PGs) subtype concentrations and clinical disease activity in RA patients undergoing long-term MTX treatment.
Methods: In this cross-sectional study, patients on a stable dose of subcutaneous MTX for several years were included.
Article Synopsis
- The effectiveness of oral anticoagulants in treating pulmonary arterial hypertension (PAH) is uncertain, with research showing mixed results regarding their safety and efficacy.
- In contrast, oral anticoagulants are essential for managing chronic thromboembolic pulmonary hypertension (CTEPH) and are recommended to prevent recurring blood clots.
- The selection of vitamin K antagonists versus direct oral anticoagulants involves weighing their pros and cons, especially considering drug interactions with other medications for PAH and CTEPH treatment.
Tinzaparin, an alternative to subcutaneous unfractionated heparin, in patients with severe and end-stage renal impairment: a retrospective observational single-center study.
J Thromb Haemost
October 2024
Article Synopsis
- Tinzaparin may offer a more manageable treatment option than unfractionated heparin for patients with severe renal impairment, but there's limited data on its pharmacokinetics and complications in this group.
- This study aimed to analyze the pharmacokinetics of tinzaparin and evaluate bleeding and thrombotic complications in patients with an estimated glomerular filtration rate (eGFR) under 30 mL.min⁻.
- Results showed that tinzaparin's pharmacokinetics were similar to those in patients without renal impairment, with low rates of major bleeding and no thrombotic complications, indicating it could be a viable alternative for these patients.
Background: Bariatric surgery (BS) induces significant changes in gastrointestinal anatomy, potentially influencing the pharmacokinetics of orally administered drugs such as rivaroxaban.
Objectives: This phase 1 study aimed to assess the pharmacokinetics and safety of full-dose rivaroxaban in post-BS patients.
Methods: The ABSORB (Rivaroxaban Pharmacokinetics and Pharmacodynamics After Bariatric Surgery and in Morbid Obesity) study was a single-center, nonrandomized, multiple-dose, parallel-design bioequivalence trial.
Eye drops containing steroids and antibiotics are widely used to treat a large range of ocular diseases of the ocular surface. They require frequent instillation or a high dosage, which can affect quality of life. We developed a biomaterial from human umbilical cord that can be loaded with drugs before being placed in the inferior conjunctival fornix.
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