ED₅₀ and ED₉₅ of intrathecal levobupivacaine with opioids for Caesarean delivery.

Background: This prospective randomized double-blind dose-response study aimed to determine the ED₅₀ and ED₉₅ of intrathecal levobupivacaine combined with morphine and sufentanil for elective Caesarean delivery.

Methods: Parturients undergoing elective Caesarean delivery were included and allocated to five levobupivacaine dose groups (6, 8, 10, 12, or 14 mg). Combined spinal-epidural (CSE) anaesthesia was performed, allowing intrathecal administration of the allocated dose of levobupivacaine with intrathecal morphine 100 µg and intrathecal sufentanil 2.

Optimal remifentanil dose for laryngeal mask airway insertion when co-administered with a single standard dose of propofol.

Purpose: This dose-response study aimed to determine the optimal dose of remifentanil combined with propofol 2.5 mg.kg(-1) iv in order to achieve excellent conditions for laryngeal mask airway (LMA) insertion in 95% of adult female patients.