Environmentally relevant concentrations of DBDPE (decabromodiphenyl ethane) induce intestinal toxicity in silkworms (Bombyx mori L.).

Decabromodiphenyl ethane (DBDPE) is one of the most extensively used novel brominated flame retardants, and it has been frequently detected in the global environment. Although organisms encounter various pollutants through the intestine, the toxicity effects of DBDPE exposure on the intestine and the potential mechanisms remain unclear. Here, by morphological observation, histopathology, high-throughput sequencing, and transcriptomics methods, we evaluated the effects of environmental (0.

Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death.

Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonodynamic therapy (SDT), aimed at enhancing the efficacy of programmed cell death protein 1 (PD-1) inhibitors by inducing robust ICD responses.

Relative fat mass is a valuable predictor of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in aging males: clinical implications.

Background: The global prevalence of lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) escalates, with obesity recognized as a major contributing factor. However, the association between the relative fat mass (RFM) and LUTS/BPH remains unexplored. This 7-year follow-up study aimed to investigate the cross-sectional and longitudinal relationships between RFM and LUTS/BPH.

Scheme for a bidirectionally pumped quantum light source on a silicon chip.

Large-scale quantum photonic circuits require integrating multiple single-photon sources, which are typically based on spontaneous four-wave mixing (SFWM) in spiral waveguides or microring resonators (MRRs). Photons can be generated in both clockwise (CW) and counterclockwise (CCW) orientations from a single source in a Sagnac configuration, showing promise for improving scalability. In this work, we propose a fully integrable scheme for bidirectional creation and usage of single photons.

Misalignment tolerance enhancement of vector beams in a free-space optical communication link.

Optical misalignment between transmitter and receiver leads to power loss and mode crosstalk in a mode division multiplexing (MDM) free-space optical (FSO) link. We report both numerical simulations and experimental results on the propagation performance of two typical vector beams, C-point polarization full Poincaré beams (FPB), and V-point polarization cylindrical vector beams (CVB), compared to homogeneous polarization scalar vortex beams (SVB) under optical misalignment. The FSO communication performance under misalignment using different transmit beams is evaluated in terms of power loss, mode crosstalk, power penalty, etc.