Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis.

Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.

Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment.

Background: Recent studies have highlighted the distinct ratio of PD-1 + Treg/PD-1 + CD8 for prognosis prediction. However, it remains unclear about the association of this ratio and tertiary lymphoid structures (TLS) with prognosis and response to neoadjuvant or conversion therapy in advanced gastric cancer.

Methods: Firstly, fresh postoperative samples from 68 gastric cancer patients in Renji Hospital were collected.

New Contributions on Species Diversity of Genus and s.l. in China.

Southwest China is extremely rich in fungal resources, and a large number of new taxa have been discovered in recent years. In the present study, we examined 26 specimens of the genera and sensu lato, most of which were obtained in Yunnan Province. Through ITS-nrLSU- phylogenetic analysis, combined with morphological studies and geographic analyses, five new species were described, viz.

A Space Telescope Scheduling Approach Combining Observation Priority Coding with Problem Decomposition Strategies.

With the increasing number of space debris, the demand for telescopes to observe space debris is also constantly increasing. The telescope observation scheduling problem requires algorithms to schedule telescopes to maximize observation value within the visible time constraints of space debris, especially when dealing with large-scale problems. This paper proposes a practical heuristic algorithm to solve the telescope observation of space debris scheduling problem.

Identification of two distinct clusters in membranous lupus nephritis patients: recognition of a high-risk profile based on unsupervised analysis.

Background And Hypothesis: Membranous lupus nephritis (MLN) traditionally includes class V (alone) and may be associated with other classes (III or IV). The clinical, therapeutic and prognosis relevance of the classification remains controversial.

Methods: A retrospective cohort of 412 MLN patients from the First Affiliated Hospital of Sun-Yat Sen University was followed for a median of 65.