Multitracer PET/CT with [F]Fluorodeoxiglucose and [F]Fluorocholine in the Initial Staging of Multiple Myeloma Patients Applying the IMPeTus Criteria: A Pilot Study.

Initial staging of patients diagnosed with multiple myeloma (MM) can lead to negative results using conventional diagnostic imaging workup, including [F]Fluorodesoxiglucose ([F]FDG) PET/CT. The aim of this prospective pilot study was to evaluate the diagnostic efficacy of [F]Fluorocholine ([F]FCH) PET/CT in the initial staging of MM patients who were candidates for autologous bone marrow transplant. : The inclusion criteria of our study were: (a) patients diagnosed with MM; (b) candidates for autologous bone marrow transplant (AT); and (c) studied with [F]FCH PET/CT and [F]FDG PET/CT for initial staging less than 4 weeks apart.

[F]FDG PET/CT in the Evaluation of Melanoma Patients Treated with Immunotherapy.

Immunotherapy is based on manipulation of the immune system in order to act against tumour cells, with growing evidence especially in melanoma patients. The challenges faced by this new therapeutic tool are (i) finding valid evaluation criteria for response assessment; (ii) knowing and distinguishing between "atypical" response patterns; (iii) using PET biomarkers as predictive and response evaluation parameters and (iv) diagnosis and management of immunorelated adverse effects. This review is focused on melanoma patients analysing (a) the role of [F]FDG PET/CT in the mentioned challenges; (b) the evidence of its efficacy.

Unusual Uptake of [I] in a Tenosynovial Giant Cell Tumour Relapse in a Patient with Differentiated Thyroid Cancer.

A 77-year-old woman with follicular thyroid cancer underwent total thyroidectomy and subsequent Iodine-131 remnant ablation. She had a history of a wide tenosynovial giant cell tumor (TGCT) of the right wrist and hand that had been resected thirteen years ago. Post-therapeutic scintigraphy and single photon emission computed tomography showed mild uptake on the distal right forearm, wrist and hand.