Publications by authors named "X Balguerie"
Biologics combined with conventional systemic agents for the treatment of children with severe psoriasis. Real-life data from the BiPe cohorts and a practice survey among French and Italian pediatric dermatologists.
Dermatol Ther
November 2022
Article Synopsis
- - Combined therapies in treating childhood psoriasis involve using multiple drugs to enhance effectiveness and minimize side effects, with a study evaluating their use in 170 children across France and Italy.
- - Out of the participants, 13% received various combinations of conventional and biologic medications, achieving significant improvements in psoriasis scores, despite reporting a few serious adverse events with positive outcomes.
- - A survey of 61 dermatologists revealed that 64% have used or intend to use these combined therapies, primarily to boost the effectiveness of biologic treatments when initial results are insufficient.
Background: Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children.
Objective: To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type).
Article Synopsis
- The study aimed to analyze the clinical practice and safety of switching biologics among pediatric psoriasis patients in the BiPe cohort, which included 134 patients.
- Out of the patients, 29 switched biologics mainly due to loss of efficacy, with most transitions occurring from etanercept to adalimumab or ustekinumab.
- The research found no significant differences in drug survival rates based on whether the biologics were used as first-line or second-line treatments, indicating a need for more data to guide switching in clinical practice.
Background: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal IgM gammopathy. Overactivation of the interleukin(IL)-1 system is reported, even though the exact pathophysiological pathways remain unknown.
Objective: To determine v cytokine profiles of Peripheral Blood Mononuclear Cells (PBMCs) from SchS patients prior to treatment and after initiation of anti-IL-1 therapy (anakinra).