Automated Machine Learning of Interfacial Interaction Descriptors and Energies in Metal-Catalyzed N and CO Reduction Reactions.

The applications of machine learning (ML) in complex interfacial interactions are hindered by the time-consuming process of manual feature selection and model construction. An automated ML program was implemented with four subsequent steps: data distribution analysis, dimensionality reduction and clustering, feature selection, and model optimization. Without the need of manual intervention, the descriptors of metal charge variance (Δ) and electronegativity of substrate (χ) and metal (δχ) were raised up with good performance in predicting electrochemical reaction energies for both nitrogen reduction reaction (NRR) and CO reduction reaction (CORR) on metal-zeolites and MoS surfaces.

Hepatitis B Virus X Protein promotes VWF-mediated HCC progression through ST8SIA6-AS1/miR-3150b-3p/ASCL1 axis.

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors, often with a poor prognosis. The HBx protein, encoded by the hepatitis B virus (HBv), is significantly associated with the pathogenesis of HCC. Although studies suggested that the von Willebrand factor (vWF) is key to the progression of HCC associated with HBv, the underlying mechanisms are largely obscure.

Risk assessment of persistent incidental pulmonary subsolid nodules to guide appropriate surveillance interval and endpoints.

Guidelines for the follow-up of pulmonary subsolid nodule (SSN) vary in terms of frequency and criteria for discontinuation. We aimed to evaluate the growth risk of SSNs and define appropriate follow-up intervals and endpoints. The immediate risk (IR) and cumulative risk (CR) of SSN growth were assessed using the Kaplan-Meier method according to nodule consistency and size.

Polystyrene Nanoplastics Hitch-Hike the Gut-Brain Axis to Exacerbate Parkinson's Pathology.

The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence of these synthetic materials. Parkinson's disease (PD) is a major neurological disorder clinically characterized by intracellular Lewy-body inclusions and dopaminergic neuronal death. These pathological hallmarks of PD, according to Braak's hypothesis, are mediated by the afferent propagation of α synuclein (αS) via the enteric nervous system, or the so-called gut-brain axis.

Proteomics analysis reveals the antagonistic interaction between high CO and warming in the adaptation of the marine diatom Thalassiosira weissflogii in future oceans.

While it is known that warming and rising CO level might interactively affect the long-term adaptation of marine diatoms, the molecular and physiological mechanisms underlying these interactions in the marine diatom Thalassiosira weissflogii on an evolutionary scale remain largely unexplored. In this study, we investigated the changes in metabolic pathways and physiological responses of T. weissflogii under long-term ocean acidification and/or warming conditions (∼3.