Correlation Between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and the Co-Occurrence of Left Ventricular Hypertrophy in Patients with Hypertension.

The aim of this study was to explore the association between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism in the 16th intron and the occurrence of left ventricular hypertrophy (LVH) in hypertensive individuals.This study included 269 patients with hypertension from Dushu Lake Hospital Affiliated to Soochow University who underwent echocardiographic examinations. Among them, 55 patients had hypertension combined with LVH, while 214 patients with hypertension did not have LVH, serving as the case and control groups, respectively.

Core-shell structured waste paper/biocarbon composite providing exceptional electromagnetic interference shielding and flame retardancy.

The widespread use of electronic devices significantly facilitates daily human life, but also leads to increasingly serious electromagnetic pollution. Therefore, it is necessary to develop eco-friendly electromagnetic interference (EMI) shielding materials with excellent overall performance. Here, we prepare a waste paper/biocarbon (WP/BC) composite with a distinct densely self-bonded core-shell structure through the partial dissolution co-mixing process.

Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway.

Ischemic stroke represents a predominant cause of morbidity and mortality globally, resulting from abrupt vascular occlusion or rupture, which precipitates considerable neuronal damage. This study aims to shed more light on the specific neuroprotective mechanisms of Kirenol, a bioactive diterpene derived from traditional herbal medicine, with a particular focus on its regulation of mitochondrial dynamics via the CK2/AKT signalling pathway and its impact on the mitochondrial fusion protein Optic atrophy 1 (Opa1). The effects of Kirenol on neuronal viability, mitochondrial function, and pertinent signalling pathways were evaluated by employing a middle cerebral artery occlusion (MCAO) model in rats and subjecting HT22 neuronal cells to oxidative stress.

Proteomics of Sternaspis chinensis to understand phosphate biomineralization in annelids.

Organisms with phosphate hard tissues contribute to the evolutionary history of life and global biogeochemical cycles. The annelid Sternaspidae is an important group of phosphate-mineralizing organisms, known for its unique amorphous phosphate ventro-caudal shield. However, the molecular mechanisms underlying the formation of their phosphate shields remain unclear.

Sesquiterpenoids isolated from the root bark of Lycium chinense.

This study reports the isolation of 11 previously undescribed sesquiterpenoids from the root bark of Lycium chinense Mill, including a 1,10-secoeudesmane-type sesquiterpene (1), a 9,10-secoeudesmane-type sesquiterpene (2) and nine rearranged eudesmane sesquiterpenes (3-11). Structures elucidation of these compounds was established using 1D/2D NMR, electronic circular dichroism calculations along with DP4 probability analysis, and X-ray diffraction analysis of single crystals. Lyciiterpenoid E (1), a eudesmane sesquiterpenoid, is characterised by a bond cleavage between C-1 and C-10 while, lyciiterpenoid F (2) exhibits a bond cleavage between C-9 and C-10.