Mechanisms of He Shi Yu Lin formula in treating premature ovarian insufficiency: insights from network pharmacology and animal experiments.

Objective: He Shi Yu Lin Formula (HSYLF) is a clinically proven prescription for treating premature ovarian insufficiency (POI), and has shown a good curative effect. However, its molecular mechanisms are unclear. This study aimed to investigate the molecular mechanisms of HSYLF and clarify how network pharmacology analysis guides the design of animal experiments, including the selection of effective treatment doses and key targets, to ensure the relevance of the experimental results.

AnkleImage - An ultrafast ultrasound image dataset to understand the ankle joint muscle contractility.

The role of the human ankle joint in activities of daily living, including walking, maintaining balance, and participating in sports, is of paramount importance. Ankle joint dorsiflexion and plantarflexion functionalities mainly account for ground clearance and propulsion power generation during locomotion tasks, where those functionalities are driven by the contraction of ankle joint skeleton muscles. Studies of corresponding muscle contractility during ankle dynamic functions will facilitate us to better understand the joint torque/power generation mechanism, better diagnose potential muscular disorders on the ankle joint, or better develop wearable assistive/rehabilitative robotic devices that assist in community ambulation.

[Investigating jellyfish diet with DNA macrobarcoding: A case study in ].

We investigated food composition and feeding selectivity of jellyfish () from the coastal aquaculture ponds in Liaodong Bay by DNA metabarcoding technology. The DNA from environmental water samples and stomach contents of were extracted and sequenced by high-throughput sequencing with 18S rDNA V4 region and mitochondrial cytochrome c oxidase subunit I (COI) as metabarcoding markers. Based on 18S rDNA metabarcoding, we detected 27 phyla in the stomach contents of , in which Mollusc was the dominant phylum followed by Arthropod, and 34 phyla in the environmental water samples, in which Pyrrophyta was the dominant phylum followed by Ciliophora and Ascomycota.

Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis.

Non-alcoholic steatohepatitis (NASH) is the most common cause of chronic liver diseases with its pathophysiological mechanism poorly understood. In this work, serological, histological, molecular biological, biochemical, and immunological methods were applied to explore the pathological significance and action of zinc finger protein 281 (ZFP281 in mouse, ZNF281 in human) and targeted strategies. We reported that ZFP281/ZNF281 abundance in hepatocytes was positively correlated with the progression of NASH.

Enhancing Post-Surgical Wound Care in Anorectal Diseases: A Comparative Study of Advanced Convolutional Neural Network (CNN) Architectures for Image Classification and Analysis.

Aim: Anorectal diseases, often requiring surgical intervention and careful post-operative wound management, pose substantial challenges in healthcare. This study presents a novel application of artificial intelligence, specifically machine learning, aimed at improving the classification and analysis of post-surgical wound images. By doing so, it seeks to enhance patient outcomes through personalized and optimized wound care strategies.