Preliminary application of EPID three-dimensional dose reconstruction in in vivo dose verification of breast cancer intensity-modulated radiation therapy.

A preliminary study was conducted using electronic portal imaging device (EPID) based dose verification in pre-treatment and in vivo dose reconstruction modes for breast cancer intensity-modulated radiation therapy (IMRT) technique with known repositioning set-up errors. For 43 IMRT plans, the set-up errors were determined from 43 sets of EPID images and 258 sets of cone beam computed tomography images. In-house developed Edose software was used to reconstruct the dose distribution using the pre-treatment and on-treatment (in vivo) EPID acquired fluence maps.

Dual Mechanism for Transient Capacitance Anomaly in Improper Ferroelectrics.

Negative capacitance (NC) effects in ferroelectrics can potentially break fundamental limits of power dissipation known as "Boltzmann tyranny." However, the origin of transient NC of ferroelectrics, which is attributed to two different mechanisms involving free-energy landscape and nucleation, is under intense debate. Here, we report the coexistence of transient NC and an S-shaped anomaly during the switching of ferroelectric hexagonal ferrites capacitor in an RC circuit.

Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA production.

Mitochondrial endonuclease G (EndoG) contributes to chromosomal degradation when it is released from mitochondria during apoptosis. It is presumed to also have a mitochondrial function because EndoG deficiency causes mitochondrial dysfunction. However, the mechanism by which EndoG regulates mitochondrial function is not known.

Association between serum vitamin D and severe headache or migraine: A population-based analysis.

Background: Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.

Photo-induced amidation/Smiles rearrangement of alkenes for synthesizing quaternary-carbon-containing succinyldiamides.

Succinyldiamide derivatives are important structural motifs in various natural products, pharmaceuticals, and functional materials. Herein, a novel, mild, and environmentally friendly method was developed for synthesizing functionalized succinyldiamides each containing a quaternary carbon center. This strategy was designed to involve photocatalytic decarboxylation of readily available oxalic monoamide using a non-precious metal photocatalyst, 4CzIPN, followed by a free-radical addition/Smiles rearrangement cascade reaction of -aryl--(arylsulfonyl)acrylamides.

Thermosensitive liposome-encapsulated gold nanocages for photothermal-modulated drug release and synergistic photothermal therapy.

Delivery nanosystems have been widely developed to improve the efficacy of chemotherapy. However, their performance regarding the non-specific leakage of drugs remained unsatisfactory. Herein, gold nanocages (AuNCs) were used as carriers and thermo-sensitive liposome (TSL) as a protective shell to design a camptothecin (CPT)-loaded delivery nanosystem (AuNCs/CPT@TSL) for photothermal-modulated drug release.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Superdiffusive Thermal Transport in Polymer-Grafted Nanoparticle Melts.

In contrast to normal diffusion processes, thermal conduction in one-dimensional systems is anomalous. The thermal conductivity is found to vary with the length as κ∼L^{α}(α>0), but there is a long-standing debate on the value α. Here, we present a canonical example of this behavior in polymer-grafted spherical nanoparticle (GNP) melts at fixed grafting density and nanoparticle radius.

Health behavior and medical insurance under the healthy China strategy: a moral hazard perspective.

Introduction: High medical expenditure is one of the major obstacles to achieving common prosperity in China. As a health risk compensation and protection mechanism, medical insurance has played a good role in alleviating the economic burden of patients. However, due to the existence of moral hazard, medical insurance may also lead to the occurrence of psychological deviation and overtreatment of patients or hospitals' health treatment expectations, thus generating unnecessary pressure on public financial expenditure.

Gut microbiota mediated T cells regulation and autoimmune diseases.

Gut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures in AIDs are revealed by advanced sequencing and metabolomics studies.

Alterations of synaptic plasticity and brain oscillation are associated with autophagy induced synaptic pruning during adolescence.

Adolescent brain development is characterized by significant anatomical and physiological alterations, but little is known whether and how these alterations impact the neural network. Here we investigated the development of functional networks by measuring synaptic plasticity and neural synchrony of local filed potentials (LFPs), and further explored the underlying mechanisms. LFPs in the hippocampus were recorded in young (21 ~ 25 days), adolescent (1.

Microarchitecture and Crystalline Composition: A Comprehensive Exploration of Salivary Gland Stones.

Objective: To investigate the microarchitecture and crystalline composition of sialoliths and to explore their formation mechanisms.

Methods: Sixty-six sialolith samples (51 from the submandibular glands and 15 from the parotid glands) were retrospectively collected. Their diameter and quality were measured.

Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice.

Ovarian function declines significantly as females enter middle-age, but the mechanisms underlying this decline remain unclear. Here, we utilize whole-organ imaging to observe a notable decrease in ovarian blood vessel (oBV) density and angiogenesis intensity of middle-aged mice. This leads to a diminished blood supply to the ovaries, resulting in inadequate development and maturation of ovarian follicles.

Unravelling nonclassical beam damage mechanisms in metal-organic frameworks by low-dose electron microscopy.

Recent advances in direct electron detectors and low-dose imaging techniques have opened up captivating possibilities for real-space visualization of radiation-induced structural dynamics. This has significantly contributed to our understanding of electron-beam radiation damage in materials, serving as the foundation for modern electron microscopy. In light of these developments, the exploration of more precise and specific beam damage mechanisms, along with the development of associated descriptive models, has expanded the theoretical framework of radiation damage beyond classical mechanisms.

Estimating the prevalence of six common respiratory viral infections in Zhangzhou, China using nasopharyngeal swabs in adults and throat swabs in Children.

Acute respiratory viral infections are a major public health concern worldwide, causing significant morbidity and economic burden. Understanding the epidemiological characteristics of these infections is crucial for effective control and prevention measures. The study aimed to investigate the epidemiology of six common respiratory viral infections in Zhangzhou, Fujian Province, China.

Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study.

Coronavirus disease 2019 (COVID-19) can lead to persistent symptoms, sequelae, and other medical complications that may last for weeks or months after recovery. The aim of the study is to assess the prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province, China, to aid in its recognition, prevention, and treatment. Between July and August 2022, 960 individuals with confirmed SARS-CoV-2 infection in Hainan, China, were recruited.

Evaluating the ability of large language models to emulate personality.

For social sciences, recent advancements in Large Language Models (LLMs) have the potential to revolutionize the study of human behaviors by facilitating the creation of realistic agents characterized by a diverse range of individual differences. This research presents novel simulation studies assessing GPT-4's ability to role-play real-world individuals with diverse big five personality profiles. In simulation 1, emulated personality responses exhibited superior internal consistency, but also a more distinct and structured factor organization compared to the human counterparts they were based on.

Deep learning-based discovery of compounds for blood pressure lowering effects.

The hypotensive side effects caused by drugs during their use have been a vexing issue. Recent studies have found that deep learning can effectively predict the biological activity of compounds by mining patterns and rules in the data, providing a potential solution for identifying drug side effects. In this study, we established a deep learning-based predictive model, utilizing a data set comprised of compounds known to either elevate or lower blood pressure.

Assessment of soil classification based on cone penetration test data for Kaifeng area using optimized support vector machine.

Soil classification and analysis are essential for understanding soil properties and serve as a foundation for various engineering projects. Traditional methods of soil classification rely heavily on costly and time-consuming laboratory and in-situ tests. In this study, Support Vector Machine (SVM) models were trained for soil classification using 649 Cone Penetration Test (CPT) datasets, specifically utilizing cone tip resistance ([Formula: see text]) and sleeve friction ([Formula: see text]) as input variables.

Newton-Simpson-based predictor-corrector methods for milling chatter stability prediction.

Milling chatter, a form of self-excited vibration, can cause significant damage in machining and manufacturing processes. By selecting appropriate milling parameters, milling chatter can be effectively mitigated without sacrificing milling efficiency. Within the framework of the semi-discretization scheme, this paper introduces the Newton-Simpson-based predictor-corrector methods to compute milling stability lobe diagrams.

Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer's disease and mild cognitive impairment patients.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. The study cohort comprised 53 AD patients, 38 MCI patients, and 39 normal control (NC) subjects.

A cross-entropy corrected hybrid multiconfiguration pair-density functional theory for complex molecular systems.

Hybrid density functionals, such as B3LYP and PBE0, have achieved remarkable success by substantially improving over their parent methods, namely Hartree-Fock and the generalized gradient approximation, and generally outperforming the second-order Møller-Plesset perturbation theory (MP2) that is more expensive. Here, we extend the linear scheme of hybrid multiconfiguration pair-density functional theory (HMC-PDFT) by incorporating a cross-entropy ingredient to balance the description of static and dynamic correlation effects, leading to a consistent improvement on both exchange and correlation energies. The B3LYP-like translated on-top functional (tB4LYP) developed along this line not only surpasses the accuracy of its parent methods, the complete active space self-consistent field (CASSCF) and the original MC-PDFT functionals (tBLYP and tB3LYP), but also outperforms the widely used complete active space second-order perturbation theory (CASPT2).

ImageDoubler: image-based doublet identification in single-cell sequencing.

Single-cell sequencing provides detailed insights into individual cell behaviors within complex systems based on the assumption that each cell is uniquely isolated. However, doublets-where two or more cells are sequenced together-disrupt this assumption and can lead to potential data misinterpretations. Traditional doublet detection methods primarily rely on simulated genomic data, which may be less effective in homogeneous cell populations and can introduce biases from experimental processes.

TOPS-speed complex-valued convolutional accelerator for feature extraction and inference.

Complex-valued neural networks process both amplitude and phase information, in contrast to conventional artificial neural networks, achieving additive capabilities in recognizing phase-sensitive data inherent in wave-related phenomena. The ever-increasing data capacity and network scale place substantial demands on underlying computing hardware. In parallel with the successes and extensive efforts made in electronics, optical neuromorphic hardware is promising to achieve ultra-high computing performances due to its inherent analog architecture and wide bandwidth.