Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.

Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice.

The autoradiographic utilization and distribution of [1-3H]-galactose by the dental tissues of ageing mice.

The uptake, turnover and distribution of [1-3H]-galactose by periodontal tissues associated with maxillary first molars of mice 5, 26 and 78 weeks of age showed that galactose was utilized by all oral tissues studied throughout the life-span. Uptake and turnover of the tracer revealed pulsed events. Synchrony of the pulsed events was noted.

Phototoxicity of the chemotherapeutic agents hematoporphyrin D, meso-tetra(p-sulfophenyl)porphine and zinc-tetra(p-sulfophenyl)porphine.

Interest in natural and synthetic porphyrins as tumor-localizing agents, tumor-photoinactivating agents and anti-trypanosomal drugs prompted a laboratory evaluation of the phototoxic potency of these compounds. At UV wavelengths greater than 3200A three porphyrin compounds were significantly more phototoxic than the positive control, 6,8-dichloro-2-phenyl-alpha-2-piperidyl-4-quinoline methanol. Phototoxicity was seen after intraperitoneal administration but not after oral administration.

Model of the antimicrobial silver uracil.

A model is proposed for the antimicrobial agent, silver uracil, whereby silver interacts with uracil forming a silver uracil combination with the silver in the +1 state intercalating between stacked uracils in a manner similar to a 'sandwich' model. The uracils maintain stability by hydrogen bonding with the water solvent, and 'flip-flop' through an antiparallism mode at 220 degrees. The silver bonds to the uracil by a charge transfer mechanism, increasing the nuclear shielding field of the pyrimidine.

Antimalarials: screening of (orally administered) silver solfonamides against Plasmodium berghei.

Orally administered silver sulfadiazine is effective against Plasmodium berghei. Attempts to synthesize an active analogue with antimalarial activity failed. Although several of the analogues were chemically stable (like silver sulfadiazine) in sodium chloride, none of the analogues were biologically active.

Orally-administered silver sulfadiazine: chemotherapy and toxicology in CF-1 mice; Plasmodium berghei (Malaria) and Pseudomonas aeruginosa.

Silver sulfadiazine when administered orally and subcutaneously to CF-1 mice in doses not exceeding 1,050 mg/kg proved to have minimal toxicity. No pathology or abnormal reactions were seen in CF-1 mice after receiving 1,050 mg/kg orally and subcutaneously once a day for 30 days. Silver sulfadiazine in doses of 1,050 mg/kg, once a day for 5 days cured mice of Plasmodium berghei even after splenectomy.