Comparison of the effectiveness of 4 anti-inflammatory drops in relieving photophobia after pupil dilation.

Purpose: To compare the relative effectiveness of diclofenac, flurbiprofen, ketorolac, and prednisolone acetate in relieving photophobia after pupil dilation for fundus examination.

Setting: Eye, Ear, Nose, and Throat Hospital, New Orleans, Louisiana, USA.

Methods: This prospective, blind, placebo-controlled study comprised 105 patients randomly assigned to 1 of 10 treatment groups.

Combined trabeculectomy and phacoemulsification: a one-site vs a two-site approach.

Purpose: To compare the results of combined trabeculectomy and phacoemulsification surgery with intraocular lens implant by means of a one-site vs a two-site approach.

Methods: Glaucomatous patients with a coexisting cataract were randomly assigned to undergo either a one-site or two-site combined procedure. One-site surgery was performed with a limbus-based conjunctival flap and scleral tunnel at the 12-o'clock position.

Topical carbonic anhydrase inhibitors.

Dorzolamide, a topically active carbonic anhydrase inhibitor, is an effective new glaucoma medication that creates a decrease in intraocular pressure similar to that produced by beta-blockers. When beta-blockers are contraindicated, dorzolamide may be used as a first-line therapy. It has excellent additivity with other topical ocular hypotensive medications, including beta-blockers and pilocarpine.

Inhibition of tumor implantation at sites of trauma by plasminogen activators.

The authors report on the influence of plasminogen activators (PA) on implantation of TA3Ha mammary tumor cells in the healing hepatic wounds of syngeneic strain A mice. Intravenously injected TA3Ha cells, although they rarely metastasize to the liver, formed tumors in the hepatic wounds of a significant percent (42%, P less than 0.0001) of mice.