Clinical trial of propranolol in post-traumatic neuralgia.

In view of several case reports of relief of various neuralgias by propranolo, a double-blind cross-over trial using this drug was conducted in 10 patients with severe persistent pain and paraesthesiae following upper limb peripheral nerve injuries. The patients received up to 240 mg of propranolol per day. Only one patient reported pain relief, but this patient withdrew from the trial.

Pain in avulsion lesions of the brachial plexus.

Traction lesions of the brachial plexus are becoming more frequent. Many of the lesions involve avulsion of nerve roots from the spinal cord. This very often results in severe pain which is associated with deafferentation.