Involvement of pallidothalamic circuitry in working memory.

This study evaluated the capacity of mu-opioid and glutamate receptor agonists to differentially regulate the involvement of the GABAergic projection from the ventral pallidum to the mediodorsal thalamus in working memory and locomotor activity. Microinjection of either the ionotropic glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) or the mu agonist [D-Ala(2),N-Me-Phe(4),Gly-ol(5)]enkephalin into the ventral pallidum of male Sprague-Dawley rats produced a dose-dependent impairment in working memory, estimated using a forced delayed alternation task in a T-maze. Performance in a spatial discrimination task without delay was also impaired by glutamate, but not by mu receptor, stimulation.

Biochemical markers of acute myocardial infarction: strategies for improving their clinical usefulness.

We investigated the early diagnostic utility, including incremental value, of the serum cardiac markers creatine kinase (CK), CK-MB (mass and activity measurements), cardiac troponin T, and myoglobin in the diagnosis of acute myocardial infarction (AMI) in patients presenting to a major teaching hospital with chest pain and non-diagnostic electrocardiographs (ECG). The reference diagnosis of acute myocardial infarction was made by a single, independent cardiologist using World Health Organization criteria. CK and CK-MB mass were the only significant predictors of AMI at presentation to the Emergency Department.

The changing face of pathology--an Australian perspective.

Despite Government at various levels in Australia attempting to force restraint by limiting financial resources, modern medicine and community expectations will continue to place demands on health services. The principal illnesses confronting society are unlikely to change, with conditions such as cancer, cardiovascular disease and diabetes remaining at their current prevalence. Early and more sophisticated detection and monitoring of these diseases will be required, with concomitant increases in costs.

Survey of the definition and screening of neonatal hypoglycaemia in Australia.

Objective: To determine the approach to identifying neonatal hypoglycaemia and the definition of neonatal hypoglycaemia used by neonatal paediatricians in Australian Level 3 neonatal intensive care units (NICU).

Methodology: A questionnaire was sent to the 101 neonatal paediatricians in the 22 Level 3 NICU in Australia asking their method of screening for, and definition of, neonatal hypoglycaemia.

Results: Responses were received from 70 neonatal paediatricians, including all 22 directors.

Diet modification in lowering plasma cholesterol levels. A randomised trial of three types of intervention.

Objective: To compare the efficacy of three types of diet and lifestyle interventions for lowering plasma lipid levels.

Design: Randomised parallel-group trial.

Subjects And Setting: Adults with plasma cholesterol levels of 5.

A direct comparison of the measurement of a random plasma glucose and a post-50 g glucose load glucose, in the detection of gestational diabetes.

We have compared the use of a random plasma glucose measured within 2 hours of a meal and a plasma glucose measured 1 hour after a 50 g glucose load to detect pregnant patients likely to have an abnormal 100 g glucose tolerance test at 28 weeks' gestation. The 50 g glucose load detected 24 of 28 women with gestational diabetes whereas the random plasma glucose detected only 13 of these patients. The 50 g glucose load gave fewer false positives, that is, patients who had an abnormal screening test but went on to have a normal glucose tolerance test (8.

The effect of removal of profile requesting on chemical pathology requesting patterns.

We investigated the effect on pathology requesting behaviour in a metropolitan teaching hospital, following the proscription by the Health Insurance Commission of the MBA (multiple biochemical analysis) request. Our laboratory had provided a 20 test profile in response to a request for MBA until February 1991, when the MBA request was no longer accepted. During the period February to June 1991, requesting clinicians had to comply with the new requesting requirements, although they continued to receive the results of the 20 test profile because of limitations imposed by our laboratory instrumentation.

Assessment of physicians' office pathology testing: organisational considerations.

In this paper we consider organizational and design aspects of an assessment of physicians' office pathology testing, and discuss difficulties in measuring the level of performance and effectiveness of such diagnostic services. A major consideration is the trade-off between compliance with a well-defined protocol, and use of the technology in a way which resembles normal operating practice.

An evaluation of osmolality measurement by freezing point depression using micro-amounts of sample.

An evaluation of the Advanced micro-osmometer is presented. This instrument has been shown to have an excellent analytical precision (within-run CV = 0.59%, between-day CV = 0.

How accurately does the Reflotron dry-chemistry system measure plasma total cholesterol levels when used a community-screening device.

This study compared the measurements of total cholesterol levels by means of a Reflotron dry-chemistry system and a standard laboratory method with the Hitachi 705 analyser. Simultaneous blood samples were collected by finger-prick and by venepuncture from 80 volunteers. The ranges of total cholesterol levels were 3.

The pathogenesis of idiopathic hypercalciuria: evidence for parathyroid hyperfunction.

We studied the effect of calcium deprivation and loading in 17 healthy subjects and 76 patients with renal calculi. Five had primary hyperparathyroidism with an elevated plasma ionised calcium and detectable plasma parathyroid hormone. Forty-nine had idiopathic hypercalciuria, defined by a urine calcium greater than 7 mmol/day on a free diet.