Patient-Specific Analysis of Neural Activation During Spinal Cord Stimulation for Pain.

Objective: Despite the widespread use of spinal cord stimulation (SCS) for chronic pain management, its neuromodulatory effects remain poorly understood. Computational models provide a valuable tool to study SCS and its effects on axonal pathways within the spinal cord. However, these models must include sufficient detail to correlate model predictions with clinical effects, including patient-specific data.

Physicians in Kentucky Perceive Physician Assistants to Be Competent Health Care Providers.

Purpose: The use of certified physician assistants (PA) has increased throughout the US health care system. The purpose of this study was to objectively evaluate physicians' perceptions of PAs' mastery of specific skills. It is important to understand stakeholders' perceptions of PAs' capabilities to support future changes in policies for better utilization of PAs in our health care system.

Incorporating Online and In-person Book Clubs into Sociology Courses.

Previous research has examined the use of nontraditional readings, particularly fiction, as a tool for teaching sociological concepts. Few studies have specifically looked at nonfiction monographs and ethnographies. This paper extends prior research by exploring how in-person and online book clubs using nonfiction texts can be used as a tool to engage and introduce students to sociological ideas.

Managing chest pain in patients with concomitant left bundle-branch block.

Diagnosis and timely management of acute myocardial infarction (MI) relies heavily on the ST-segment elevation sum. Presence of concomitant left bundle-branch block (LBBB) in patients presenting with possible acute MI presents a diagnostic dilemma. The LBBB pattern distorts ST-segment changes, delaying or preventing accurate diagnosis.

Randomized clinical trial of deep brain stimulation for poststroke pain.

Objective: The experience with deep brain stimulation (DBS) for pain is largely based on uncontrolled studies targeting the somatosensory pathways, with mixed results. We hypothesized that targeting limbic neural pathways would modulate the affective sphere of pain and alleviate suffering.

Methods: We conducted a prospective, double-blinded, randomized, placebo-controlled, crossover study of DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC) in 10 patients with poststroke pain syndrome.

Early Predictors of Students at Risk of Poor PANCE Performance.

Purpose: The purpose of this study was to identify early predictors in the physician assistant (PA) program curriculum that could be used to identify students "at risk" of failing the Physician Assistant National Certifying Examination (PANCE), allowing for early intervention. Previous literature implicates grades on foundational coursework as promising early predictors of PANCE performance.

Methods: Secondary data analyses were performed using student data from 2003 to 2014 school years in the PA program at a large university.

Post-exercise depression following submaximal and maximal isometric voluntary contraction.

It is well known that corticomotor excitability is altered during the post-exercise depression following fatigue within the primary motor cortex (M1). However, it is currently unknown whether corticomotor reorganization following muscle fatigue differs between magnitudes of force and whether corticomotor reorganization occurs measured with transcranial magnetic stimulation (TMS). Fifteen young healthy adults (age 23.

Identifying and managing chest pain in women.

Heart disease continues to be the leading cause of death in women in the United States. Sex disparities remain despite research highlighting the unique aspects of managing women with ischemic heart disease. Increased mortality in women may be related to the critical differences in the clinical presentation of ischemic heart disease between the sexes.

Age-related weakness of proximal muscle studied with motor cortical mapping: a TMS study.

Aging-related weakness is due in part to degeneration within the central nervous system. However, it is unknown how changes to the representation of corticospinal output in the primary motor cortex (M1) relate to such weakness. Transcranial magnetic stimulation (TMS) is a noninvasive method of cortical stimulation that can map representation of corticospinal output devoted to a muscle.

Perceived outcomes of web-based modules designed to enhance athletic trainers' knowledge of evidence-based practice.

Context: The release of evidence-based practice (EBP) Web-based learning modules to the membership of the National Athletic Trainers' Association has provided athletic trainers (ATs) the opportunity to enhance their knowledge of the various EBP concepts. Whereas increasing the knowledge of EBP among ATs is important, assessing whether this newfound knowledge is being translated into clinical practice and didactic education is crucial.

Objective: To explore the effectiveness of an educational intervention regarding EBP on the didactic instruction patterns of athletic training educators and the clinical practice behaviors of clinicians.

Future directions of evidence-based practice in athletic training: perceived strategies to enhance the use of evidence-based practice.

Context: The shift to a culture of evidence-based practice (EBP) in athletic training is a necessary step in both the optimization of patient care and the advancement of athletic trainers (ATs) as health care professionals. Whereas individuals have gained knowledge in this area, most ATs still are not practicing in an evidence-based manner. Exploring perceived strategies to enhance the use of EBP will help to determine the best approaches to assist ATs in applying EBP concepts to practice to improve patient care.

Effectiveness and neural mechanisms associated with tDCS delivered to premotor cortex in stroke rehabilitation: study protocol for a randomized controlled trial.

Background: More than 60% of stroke survivors experience residual deficits of the paretic upper limb/hand. Standard rehabilitation generates modest gains. Stimulation delivered to the surviving Primary Motor Cortex in the stroke-affected hemisphere has been considered a promising adjunct.

Neurophysiological correlates of aging-related muscle weakness.

Muscle weakness associated with aging implicates central neural degeneration. However, role of the primary motor cortex (M1) is poorly understood, despite evidence that gains in strength in younger adults are associated with its adaptations. We investigated whether weakness of biceps brachii in aging analogously relates to processes in M1.

Lack of muscle contractile property changes at the time of perceived physical exhaustion suggests central mechanisms contributing to early motor task failure in patients with cancer-related fatigue.

Context: Fatigue is one of the most common symptoms reported by cancer survivors, and fatigue worsens when patients are engaged in muscle exertion, which results in early motor task failure. Central fatigue plays a significant role, more than muscle (peripheral) fatigue, in contributing to early task failure in cancer-related fatigue (CRF).

Objectives: The purpose of this study was to determine if muscle contractile property alterations (reflecting muscle fatigue) occurred at the end of a low-intensity muscle contraction to exhaustion and if these properties differed between those with CRF and healthy controls.

Radiofrequency radiation and the immune system. Part 3. In vitro effects on human immunoglobin and on murine T- and B-lymphocytes.

Radiofrequency radiation (RFR) altered the physical separation of immunoglobulin (Ig) and of T- and B-lymphocytes during liquid gel chromatography. Exposure of human serum to a 10 MHz electric field (8500 V/m, less than or equal to 0.134 W kg-1) during chromatography resulted in accelerated elution of the IgM, IgA and IgG fractions.

Indium-114m in dual-nuclide studies with Cr-51: comparison with indium-111.

Simultaneously radioassay of In-111 and In-114m, each in the presence of Cr-51, has been investigated. Presented here are data demonstrating the efficacy of using In-114m in a dual radioassay with Cr-51, a radiolabel currently used in many cellular research applications. In-111 (T1/2, 2.