Publications by authors named "Wuxiang Sun"

Article Synopsis
  • Alzheimer's disease (AD) is a major health issue, and current research is focusing on the role of blood vessels and potential blood biomarkers for diagnosis, as well as remote ischemic conditioning (RIC) as a preventive strategy.
  • In a study, female wild-type and APP/PS1 transgenic rats underwent RIC and were tested for cognitive and depressive behaviors, while various biological evaluations were conducted to understand RIC's effects.
  • The results showed that RIC improved memory-related proteins, alleviated depressive behaviors, and protected the neurovascular unit in the rats, suggesting it may have potential benefits for preventing AD.
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Brain-derived estrogen (BDE2) is gaining attention as an endogenous neurotransmitter. Recent research has revealed that selectively removing the aromatase gene, the pivotal enzyme responsible for BDE2 synthesis, in forebrain neurons or astrocytes can lead to synaptic loss and cognitive impairment. It is worth noting that remote ischemia post-conditioning (RIP), a non-invasive technique, has been shown to activate natural protective mechanisms against severe ischemic events.

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Although 17β-estradiol (E2) can be locally synthesized in the brain, whether and how brain-derived E2 (BDE2) impacts neurogenesis with aging is largely unclear. In this study, we examined the hippocampal neural stem cells, neurogenesis, and gliogenesis of 1, 3, 6, 14, and 18-month (Mon) female rats. Female forebrain neuronal knockout (FBN-ARO-KO) rats and letrozole-treated rats were also employed.

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Brain-derived estrogen is an endogenous neuroprotective agent, whether and how might this protective function with aging, especially postmenopausal drops in circulating estrogen, remain unclear. We herein subjected 6, 14, and 18 Mon female rats to mimic natural aging, and found that estrogen synthesis is more active in the healthy aged brain, as evidenced by the highest levels of mRNA and protein expression of aromatase, the key enzyme of E2 biosynthesis, among the three groups. Aromatase knockout in forebrain neurons (FBN-Aro-/-) impaired hippocampal and cortical neurons, and cognitive function in 18 Mon rats, compared to wild-type controls.

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Multi-degrees of freedom piezo-driven precision positioning platforms with large working strokes are demanded in many research fields. Although many multi-degrees of freedom piezo-driven positioning platforms have been proposed, few of them can achieve both large working stroke and high speed, which hinders their applications. In this study, a two-degrees of freedom piezo-driven positioning platform was proposed by stacking two identical stick-slip piezoelectric actuators.

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The angle between the piezoelectric stack (PES) and the mover would significantly affect the output performances of stick-slip piezoelectric actuators in theory; however, this issue has not been explored. Accordingly, in this paper, to investigate the effects of the angle, a stick-slip piezoelectric actuator with a changeable angle between the PES and the mover was proposed, and its structure was briefly introduced first. Then, the relationship between the angle and the parasitic motion was theoretically calculated.

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