Publications by authors named "Wuwei Zhuang"
Article Synopsis
- The study focuses on identifying salivary proteins as potential biomarkers for primary Sjögren's disease (pSjD) to create a non-invasive prediction model.
- Liquid chromatography-tandem mass spectrometry was used on saliva samples to find proteins associated with immune processes, highlighting specific proteins such as CFB, CLU, and NE as independent predictors of pSjD.
- The proposed model combining these biomarkers with serum autoantibodies and Schirmer's test showed high accuracy, with a sensitivity of 84.85% and specificity of 92.45%, suggesting it could serve as a valuable non-invasive tool for pSjD classification.
Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), exhibits significant heterogeneity. Recent evidence suggests that non-immune factors contribute to end-organ damage, challenging the traditional view of LN solely arising from immune dysregulation. To investigate this, we employed autoimmune-prone mice receiving intraperitoneal pristane injections.
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