CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway.

Chemokine cysteine-X-cysteine motif ligand 8 (CXCL8) is up-regulated in many malignancies, indicating that CXCL8 takes part in tumor progression. However, the expression and function of CXCL8 in osteosarcoma remained not fully elucidated. In this study, expressions of 12 cytokines and chemokines were measured in the serum from 12 of normal controls (NCs) and 25 of osteosarcoma patients.

Identification of key genes associated with Schmid-type metaphyseal chondrodysplasia based on microarray data.

This study aimed to gain a better understanding of the molecular circuitry of Schmid-type metaphyseal chondrodysplasia (SMCD), and to identify more potential genes associated with the pathogenesis of SMCD. Microarray data from GSE72261 were downloaded from the NCBI GEO database, including collagen X p.Asn617Lys knock-in mutation (ColXN617K), ablated XBP1 activity (Xbp1CartΔEx2), compound mutant (C/X), and wild-type (WT) specimens.

A case report of children's divergent dislocation of the elbow and review of literature.

Background: The divergent dislocation of the elbow is not common in children, and the imaging is difficult and challenging. This often leads to misdiagnosis or inappropriate treatment. The literature has reported a total of 19 cases currently.

PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage.

Glycolytic disorder has been demonstrated to be a major cause of osteoarthritis (OA) and chondrocyte dysfunction. The present work aimed to investigate the expression and role of the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in OA cartilage. It was found that PFKFB3 expression was down-regulated in human OA cartilage tissues and in tumour necrosis factor (TNF)-α- or interleukin (IL)-1β-stimulated human chondrocytes.

Comparative study of serum proteomes in Legg-Calve-Perthes disease.

Background: Legg-Calve-Perthes Disease (LCPD) is an idiopathic osteonecrosis of the developing femoral head complicated by pain and disability of the hip joint. To date, the pathological mechanisms of LCPD are not well-known. This study screened the changes in serum protein expression in patients with LCPD.

MicroRNA-9 regulates osteoblast differentiation and angiogenesis via the AMPK signaling pathway.

MiR-9 has been found to be involved in the repair of spinal cord injury and regulates the proliferation and differentiation of mesenchymal stem cells. However, the role of miR-9 in repair of bone defects has not been well studied. The current study was designed to investigate its role and potential underlying mechanism in regulating osteoblast differentiation and angiogenesis.

Ulnar Rotation Osteotomy for Congenital Radial Head Dislocation.

Purpose: To evaluate an ulnar rotation osteotomy for congenital anterior dislocation of the radial head.

Methods: Nine patients (5 boys and 4 girls aged 6 to 13 years) with congenital anterior dislocation of the radial head were treated with ulnar rotation osteotomy. Magnetic resonance imaging of the elbow showed the proximal radioulnar joint on the anterior-lateral side of the ulna rather than on the lateral side in patients with congenital anterior dislocation of the radial head.

Fracture of the Lateral Process of the Talus in Children: A Kind of Ankle Injury With Frequently Missed Diagnosis.

Objective: To analyze the clinical characteristics, the treatment, and the outcome of lateral process fracture of the talus in children.

Methods: From March 2011 to October 2013, 12 children with lateral process fracture of the talus were treated in our hospital. The study contained 3 female and 9 male patients, including 8 patients affected on the left side and 4 on the right side.

Valgus Osteotomy of the Proximal Humerus to Treat Humerus Varus in Children.

Purpose: Humerus varus is a rare disease in children that can cause limited active abduction and forward flexion of the shoulder as well as upper limb length discrepancies. Valgus osteotomy of the proximal humerus is an effective method to treat this disease, although internal fixation with a plate and screws is rarely reported. The purpose of this article is to investigate the clinical outcome and radiographic changes of valgus osteotomy of the proximal humerus through internal fixation with a plate and screws.

[Three-dimensional CT imaging in the treatment of children's developmental dislocation of hip].

Objective: To investigate the value of 3-dimensional CT in the treatment of developmental dislocation of hip (DDH).

Methods: From 2003.6 to 2007.