Clinical Manifestation, Risk Factors, and Immune Checkpoint Inhibitor Rechallenge of Checkpoint Inhibitor-Associated Pneumonitis in Patients With Lung Cancer.

Immune-related adverse effects can lead to damage to various systems of the body, checkpoint inhibitor-associated pneumonitis (CIP) is one of the potentially lethal immune-related adverse effects. However, evidence regarding the risk factors associated with CIP is limited. To timely and accurate identification and prompt treatment of CIP, understanding the risk factors for multimorbidity among diverse study populations becomes crucial.

Distributed adaptive control for nonlinear multi-agent systems with nonlinear parametric uncertainties.

This paper considers the distributed tracking control problem for a class of nonlinear multi-agent systems with nonlinearly parameterized control coefficients and inherent nonlinearities. The essential of multi-agent systems makes it difficult to directly generalize the existing works for single nonlinearly parameterized systems with uncontrollable unstable linearization to the case in this paper. To dominate the inherent nonlinearities and nonlinear parametric uncertainties, a powerful distributed adaptive tracking control is presented by combing the algebra graph theory with the distributed backstepping method, which guarantees that all the closed-loop system signals are global bounded while the range of the tracking error between the follower's output and the leader's output can be tuned arbitrarily small.

The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.

In recent years, the role and mechanism of long non-coding RNA (LncRNA) in cardiovascular diseases have received increasing attention. The chemotherapy agent, doxorubicin (DOX), is one of the most effective drugs for various cancers, but its efficacy is limited by its cardiotoxicity. Therefore, further exploration is required for the molecular mechanism of DOX-induced cardiotoxicity.

Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus.

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to self-antigen, autoantibody production, and abnormal immune response. Cuproptosis is a recently reported cell death form correlated with the initiation and development of multiple diseases. This study intended to probe cuproptosis-related molecular clusters in SLE and constructed a predictive model.

The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo/in vitro, C57BL/6 mice, AC16 and hiPSC-CMs].

Recombinant human endostatin (rh-endostatin) is an anti-angiogenic drug, which is used for the treatment of advanced non-small-cell lung cancer (NSCLC) and other cancers. However, its side effects, especially the cardiotoxicity with unclear mechanisms limit its wide application in clinical practice. In this study, human cardiomyocyte cell line AC16 and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with different doses of rh-endostatin were used to analyze its effect on cardiac cell toxicity.

Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP.

Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the regulatory effects of ncRNAs. Platelets are produced upon the differentiation of hematopoietic stem cells into megakaryocytes, 10 per day, and are renewed every 8-9 days. The process of thrombopoiesis is affected by multiple factors, in which ncRNAs also exert a significant regulatory role.

Output-Feedback stabilization for stochastic nonlinear systems with Markovian switching and time-varying powers.

This paper investigates the output-feedback stabilization for stochastic nonlinear systems with both Markovian switching and time-varying powers. Specifically, by developing a novel dynamic gain method and using the Itô formula of Markovian switching systems, a reduced-order observer with a dynamic gain and an output-feedback controller are designed. By using advanced stochastic analysis methods, we show that the closed-loop system has an almost surely unique solution and the states are regulated to the origin almost surely.

Identification of Key Genes Related to Skin Burns Based on Bioinformatics Analysis.

To further understand the regulatory network and molecular mechanisms of gene expression after skin burns, we performed bioinformatics analysis of gene expression profiles of skin burn samples and identified key genes associated with skin burns. The GSE8056 and GSE139028 datasets were downloaded from the Gene Expression Omnibus database for analysis and validation. The limma package was used to screen for differentially expressed genes (DEGs).

Down-regulation of miR-let-7e attenuates LPS-induced acute lung injury in mice via inhibiting pulmonary inflammation by targeting SCOS1/NF-κB pathway.

Excessive pulmonary inflammatory response is critical in the development of acute lung injury (ALI). Previously, microRNAs (miRNAs) have been recognized as an important regulator of inflammation in various diseases. However, the effects and mechanisms of miRNAs on inflammatory response in ALI remain unclear.

Cooperative Control of Multiple Nonlinear Benchmark Systems Perturbed by Second-Order Moment Processes.

This paper studies the cooperative control problem of multiple nonlinear benchmark systems perturbed by second-order moment processes. The nonlinear benchmark system consists of a moving car and a rolling ball in oscillating surroundings. When the leader is only accessible to a small part of the followers in a directed graph, a new vectorial backstepping method is proposed for the design of distributed cooperative control laws.

Associations of childhood maltreatment with subsequent illicit drug use among Chinese adolescents: The moderating role of the child's sex.

Adolescence is a critical period for the onset of illicit drug use. This study aimed to estimate the prevalence of illicit drug use among Chinese adolescents, to assess the associations between different forms of childhood maltreatment and subsequent illicit drug use and to test whether the child's sex plays a moderating role in the associations. A secondary analysis was made of cross-sectional data collected from 10th to 12th graders from China who were sampled in the 2015 School-based Chinese Adolescents Health Survey.

[Increased expression of HMGB1 and TLR4 in intestinal tissues and intestinal immune dysfunction in severely burned rats].

Objective To investigate the expressions of high mobility group box 1 (HMGB1) and Toll-like receptor 4 (TLR4) in the intestinal tract of severely burned rats and their relationship with intestinal immune function. Methods Forty male SD rats were randomly divided into control group (n=10) and severe burn group (n=30). 60% of the rats' body (the back and ventral side) was burned in the severe burn group, and only anesthesia was performed in normal control group.

miR-27a protects against acute lung injury in LPS-treated mice by inhibiting NF-κB-mediated inflammatory response.

Acute lung injury (ALI), which is an excessive uncontrolled inflammatory response in the lung, is mediated by several pro-inflammatory mediators. Recent evidence has implicated microRNAs (miRNAs) in regulation of inflammation in different diseases. However, the roles and underlying molecular mechanism of miRNAs in ALI have not been adequately elucidated.

Downregulation of miR-181a protects mice from LPS-induced acute lung injury by targeting Bcl-2.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a progressive syndrome with a high incidence and mortality rate. Apoptosis is a very important pathological feature of ALI. Recently, more and more researches on mircoRNAs are involved in the regulation of proliferation and apoptosis of cancer cells.

Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway.

Background: Ulinastatin (ULI), a serine protease inhibitor, had been widely used as a drug for patients with acute inflammatory disorders. However, evidence regarding the anti-inflammatory effect of ulinastatin was still lacking. In this study, we investigated the protective mechanisms of ULI in LPS-induced acute lung injury (ALI).

The therapeutic efficacy of glutamine for rats with smoking inhalation injury.

Smoke inhalation injury represents a major cause of mortality in burn patients and is associated with a high incidence of pulmonary complications. Glutamine (GLN) is considered a conditionally essential amino acid during critical illness and injury. However, whether GLN could attenuate lung injury caused by smoke inhalation is still unknown.

Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice.

Acute lung injury (ALI) is a serious illness, the incidence and mortality of which are very high. Free radicals, such as hydroxyl radicals (OH) and peroxynitrite (ONOO(-)), are considered to be the final causative molecules in the pathogenesis of ALI. Hydrogen, a new antioxidant, can selectively reduce OH and ONOO(-).