Exploring the Interplay Between Vitamin B-related Biomarkers, DNA Methylation, and Gene-Nutrition Interaction in Esophageal Precancerous Lesions.

Background: Vitamin B depletion has been suggested to be associated with esophageal precancerous lesions (EPL). However, the potential mechanisms remain unclear.

Aims: This study aims to evaluate the role of vitamin B and its regulated epigenetic modification in EPL and provide preliminary information on the identification of potential molecular biomarkers for the early prediction of EPL.