Incidence of Uveitis Following Initiation of Prostaglandin Analogs Versus Other Glaucoma Medications: A Study from the SOURCE Repository.

Purpose: To evaluate the risk of incidence rates of uveitis among patients starting topical glaucoma therapy.

Design: Retrospective database study utilizing the Sight Outcomes Research Collaborative (SOURCE) Ophthalmology Data Repository.

Participants: Adult glaucoma patients who were recently started on topical glaucoma therapy.

Evaluation of Sociomedical Factors on Corneal Donor Recovery Using Machine Learning.

Purpose: To evaluate co-morbid sociomedical conditions affecting corneal donor endothelial cell density and transplant suitability.

Method(s): Corneal donor transplant information was collected from the CorneaGen eye bank between June 1, 2012 and June 30, 2016. A natural language processing algorithm was applied to generate co-morbid sociomedical conditions for each donor.

Automated Category and Trend Analysis of Scientific Articles on Ophthalmology Using Large Language Models: Development and Usability Study.

Background: In this paper, we present an automated method for article classification, leveraging the power of large language models (LLMs).

Objective: The aim of this study is to evaluate the applicability of various LLMs based on textual content of scientific ophthalmology papers.

Methods: We developed a model based on natural language processing techniques, including advanced LLMs, to process and analyze the textual content of scientific papers.

Impact of demographic factors on corneal donor recovery.

Purpose: Death-to-preservation time (DTP) is a commonly reported, but infrequently studied, measure of efficiency for the corneal tissue procurement process and is a key screening component for corneal tissue suitability for transplantation. It is unknown whether demographic factors such as race, age, or gender may affect DTP.

Methods: This retrospective cross-sectional study included all deceased-donor eye tissue collected by CorneaGen Eye Banks between June 1, 2012 and June 30, 2016.

Repeatability and reliability of semi-automated anterior segment-optical coherence tomography imaging compared to manual analysis in normal and keratoconus eyes.

Purpose: To assess the repeatability and reliability of semi-automated EyeMark Python program measurements compared to manual ImageJ image processing of anterior segment-optical coherence tomography (AS-OCT) structures in healthy and keratoconus eyes.

Methods: Heidelberg AS-OCT was used to image 25 eyes from 14 healthy subjects and 25 eyes from 15 subjects with keratoconus between the ages of 20 and 80 years, collected prospectively, in this observational case-control study. Visual axis scan containing vertical fixation light beam was selected from the 15-line AS-OCT scan raster.

Chlamydia psittaci -Induced Reactive Infectious Mucocutaneous Eruption With Ocular Involvement.

Introduction: This report highlights a postinfectious mucocutaneous inflammatory response involving the ocular surface and adnexa after Chlamydophila psittaci exposure.

Case Description: A 35-year-old man presented after a prodrome of upper respiratory symptoms with rash and mucocutaneous blistering involving the ocular and oral mucosa, causing pseudomembranous conjunctivitis and corneal epithelial defects. Extensive inflammatory and infectious workup suggested recent C.

Performance of ChatGPT in Diagnosis of Corneal Eye Diseases.

Introduction: Assessing the capabilities of ChatGPT-4.0 and ChatGPT-3.5 for diagnosing corneal eye diseases based on case reports and compare with human experts.

Association Between Socioeconomic Deprivation and Orbital Trauma in a Hospital-Based Population.

Purpose: To examine the association between area-level socioeconomic deprivation and orbital trauma among emergency ophthalmology consults.

Methods: We conducted a cross-sectional study using 5-year Epic data for all hospital-based ophthalmology consults at the University of Maryland Medical System, and the Distressed Communities Index (DCI) data for area-level socioeconomic deprivation. We ran multivariable logistic regression models adjusting for age to compute odds ratios (OR) and 95% confidence intervals (CI) for the association between the DCI quintile 5 distressed score and orbital trauma.

Weather Patterns and the Frequency of Ophthalmology Consultations in the Emergency Setting.

Purpose: To determine if weather patterns are associated with the frequency of ophthalmology consultations in the Emergency Room (ER) and trauma settings.

Methods: Hospital-based ophthalmology consultations between January 1, 2015 and December 31, 2020 at the University of Maryland Medical Center (UMMC) were included in the BALCITE (BALtimore Consultation, Inpatient, and Trauma of the Eye) database. Encounters were filtered to the general ER, the R.

Social Media Evaluation of Seasonal and Geographic Trends of Corneal Ulcers in the United States.

Objectives: The purpose of this study is to evaluate if social media and Google search data can identify seasonal and geographic trends in the incidence of corneal ulcers in the United States.

Methods: This is a case series of all corneal ulcer-related data collected from two major social media platforms and Google trends from US users between 2017 and 2021. Instagram and Twitter were searched for posts and hashtags related to "corneal ulcer.

Characteristics of Semiautomated Endothelial Cell-Density Measurements Among Corneal Donor Eyes.

Importance: Endothelial cell density in corneal donor eyes remains a critical component in selecting tissue suitable for corneal transplant.

Objective: To describe an anomaly in endothelial cell density discovered in a large cohort of corneal donor eyes.

Design, Setting, And Participants: Donor information for this cross-sectional study was obtained from the CorneaGen eye bank for donors from June 1, 2012, to June 30, 2016.

Predictors of intraocular pressure reduction after femtosecond laser-assisted cataract surgery versus conventional phacoemulsification surgery: a prospective trial.

Purpose: To evaluate the association between postoperative intraocular pressure (IOP) reduction and phacoemulsification parameters in patients who underwent both conventional phacoemulsification surgery (CPS) and femtosecond laser-assisted cataract surgery (FLACS).

Methods: This was a prospective multicenter comparative study that enrolled 90 participants who underwent cataract surgery at the University of Maryland Medical System and the Wilmer Eye Institute. Patients underwent FLACS in one eye and CPS in the fellow eye.

The detection of keratoconus using novel metrics derived by anterior segment optical coherence tomography.

Purpose: To determine through a feasibility study whether anterior and posterior corneal arc length and cross-sectional area measured using anterior segment ocular coherence tomography (AS-OCT) can distinguish between healthy and keratoconic corneas.

Methods: Patients diagnosed with keratoconus along with healthy controls underwent AS-OCT. ImageJ was used to determine the central 6 mm anterior and posterior corneal arc lengths and cross-sectional areas.

Inter-rater Reliability and Repeatability of Manual Anterior Segment Optical Coherence Tomography Image Grading in Keratoconus.

Objectives: To determine the repeatability of corneal measurements from anterior segment optical coherence tomography (AS-OCT) images using ImageJ software in healthy eyes compared with eyes with keratoconus.

Methods: Anterior segment OCT images of 25 eyes from 14 healthy subjects and 25 eyes from 15 subjects with keratoconus between the ages of 20 and 80 years were evaluated. Two trained observers used ImageJ to measure the central corneal cross-sectional area and anterior and posterior corneal arc lengths.

Estimated Prevalence of Keratoconus in the United States From a Large Vision Insurance Database.

Purpose: To estimate the prevalence of keratoconus in the United States using a large vision insurance database.

Methods: We used data from the 2016 vision service plan (VSP) Global claims database to estimate the prevalence of keratoconus among enrollees by state. The VSP Global database includes cross-sectional de-identified claims data summarized by state of residence in predefined age and gender groups.

Dexamethasone implant migration in an eye with congenital glaucoma: A case report and review of the literature.

Introduction: The dexamethasone (DEX) implant is an FDA approved treatment for diabetic macular edema, non-infectious posterior uveitis, and macular edema secondary to branch or central retinal vein occlusions. We describe a case of anterior chamber (AC) migration of a DEX implant in a patient with a history of congenital glaucoma and perform a review of the literature on this particular complication, summarizing the common risk factors, subsequent complications, and management options.

Case Description: A 46-year-old female with a history of congenital glaucoma, status post cataract extraction with insertion of intraocular lens, pars plana vitrectomy, and Baerveldt tube implant in the left eye was referred for post-operative cystoid macular edema (CME).

Effect of Body Refrigeration Time on Cornea Donor Tissue.

Purpose: To determine how early body refrigeration affects corneal donor transplant suitability and endothelial cell density.

Methods: Donor information was obtained from the CorneaGen Eye Bank including demographics, time of death to preservation, and body refrigeration status, for donors between 2012 and 2016. The death to preservation interval was classified into 3 categories: 0 to 10, 10 to 20, and 20+ hours.

Corneal Changes After Belantamab Mafodotin in Multiple Myeloma Patients.

Objectives: To describe progressive corneal microcyst-like epithelial changes (MECs) that developed in patients treated with the investigational drug belantamab mafodotin (belamaf) for refractory multiple myeloma (MM).

Methods: This is a single center case series of patients with MM receiving the investigational drug belamaf.

Results: All 12 patients included in this analysis who were treated with belamaf developed MECs that initially appeared in the peripheral cornea and progressed centrally with time.

Pediatric Corneal Structural Development During Childhood Characterized by Ultrasound Biomicroscopy.

Purpose: To quantitatively describe the structural corneal changes from infancy to early adulthood using ultrasound biomicroscopy.

Methods: In this prospective study, 168 ultrasound biomicroscopy images were obtained from 24 healthy eyes of 24 patients who consented and enrolled in the Pediatric Anterior Segment Imaging Innovation Study. Their ages ranged from birth to 26 years.

A review of imaging modalities for detecting early keratoconus.

Objectives: Early identification of keratoconus is imperative for preventing iatrogenic corneal ectasia and allowing for early corneal collagen cross-linking treatments to potentially halt progression and decrease transplant burden. However, early diagnosis of keratoconus is currently a diagnostic challenge as there is no uniform screening criteria. We performed a review of the current literature to assess imaging modalities that can be used to help identify subclinical keratoconus.

Corneal Endotheliitis Associated with a Methicillin Resistant Pyogenic Liver Abscess.

Endotheliitis is the inflammation of the corneal endothelium resulting in edema and subsequent loss of vision. Bacterial causes of corneal inflammation primarily of the epithelium with subsequent, secondary involvement of the endothelium have previously been described. Notably, however, there are no reports of isolated endotheliitis related to a bacterial pathogen.

Comparison of Preoperative Parameter Measurements Using an Optical Biometer, Automated Keratometer, and a Placido-Based Topographer Module.

Objectives: To assess the agreement of corneal power, corneal astigmatism, axis location, and astigmatic vector component measurements using a Lenstar LS900, a T-cone add-on, and an ARK 1S autorefractor, furthermore, to assess instrument agreement in a subset of astigmatic eyes.

Methods: Retrospective analysis of keratometric readings from 3 instruments for 66 eyes undergoing cataract surgery at the Maryland Veterans Affairs Medical Center from November 2014 to 2015. Agreement in corneal power, mean corneal power, axis location, and astigmatic vector components (J0, J45) between devices was evaluated.