Publications by authors named "Wuping Lai"
B7-H3 promotes nasopharyngeal carcinoma progression by regulating CD8+ T cell exhaustion.
Immun Inflamm Dis
September 2024
Article Synopsis
- - The study investigates the role of B7-H3 protein in nasopharyngeal carcinoma (NPC) and how it affects tumor growth and immune response, particularly its interaction with the co-stimulatory receptor 4-1BB on CD8+ T cells.
- - Researchers used techniques like RNA knockdown and mouse models to demonstrate that reducing B7-H3 levels leads to increased apoptosis, slower tumor growth, and reduced migration of NPC cells, both in vitro and in vivo.
- - The results reveal that B7-H3 promotes tumor growth and immune evasion by interacting with 4-1BB, causing CD8+ T cell exhaustion, thereby highlighting its potential as a target for cancer therapy.
Emerging evidence has suggested that exposure to PM is a significant contributing factor to the development of chronic obstructive pulmonary disease (COPD). However, the underlying biological effects and mechanisms of PM in COPD pathology remain elusive. In this study, we aimed to investigate the implication and regulatory effect of biomass fuels related-PM (BRPM) concerning the pathological process of fibroblast-to-myofibroblast transition (FMT) in the context of COPD.
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