Fabrication of a reusable electrochemical platform based on acid-responsive host-guest interaction with β- cyclodextrin.

A reusable electrochemical glassy carbon electrode (GCE) platform based on the acid-responsive host-guest interaction between β-cyclodextrin (β-CD) and benzimidazole (BM) derivatives was developed. The β-CD can specifically recognize the BM derivative through the acid -responsive host-guest interaction. The electrode was first modified by eletrografting to immobilize a diamine linker (Boc-EDA), resulting in GCE in which one amine was used for covalent immobilization to the electrode and another Boc protected amine was used to solid-phase synthesis on following step-by-step modifications on the electrode.

Boronates as hydrogen peroxide-reactive warheads in the design of detection probes, prodrugs, and nanomedicines used in tumors and other diseases.

Hydrogen peroxide (HO) has always been a topic of great interests attributed to its vital role in biological process. HO is known as a major reactive oxygen species (ROS) which is involve in numerous physiological processes such as cell proliferation, signal transduction, differentiation, and even pathogenesis. A plenty of diseases development such as chronic disease, inflammatory disease, and organ dysfunction are found to be relevant to abnormality of HO production.