Publications by authors named "Wumiti Taxi"
Ethnopharmacological Relevance: Wen-Shen-Tong-Luo-Zhi-Tong-Decoction (WSTLZTD) is a traditional Chinese medicine formula, and its effectiveness in the treatment of senile osteoporosis(SOP) has been confirmed by clinical studies. However, the underlying mechanism of WSTLZTD in SOP is unclear.
Aim Of The Study: This study aimed to clarify the unique effects of Wen-Shen-Tong-Luo-Zhi-Tong-Decoction(WSTLZTD) on senile osteoporosis(SOP) and its underlying mechanisms.
Background: Promoting the balance between bone formation and bone resorption is the main therapeutic goal for postmenopausal osteoporosis (PMOP), and bone marrow mesenchymal stem cells (BMSCs) osteogenic differentiation plays an important regulatory role in this process. Recently, several long non-coding RNAs (lncRNAs) have been reported to play an important regulatory role in the occurrence and development of OP and participates in a variety of physiological and pathological processes. However, the role of lncRNA tissue inhibitor of metalloproteinases 3 (lncTIMP3) remains to be investigated.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNAs (miRNAs) play a significant role in the development of autoimmune diseases, particularly rheumatoid arthritis (RA), serving as potential early diagnostic biomarkers and therapeutic targets.
- Research conducted from 2001 to 2022 identified contributions from 29 countries, with China and the U.S. being the most prolific, especially in citations and publications in leading journals.
- Key findings highlight miR-146a and miR-155 as primary areas of focus in miRNA research related to RA, demonstrating their importance in understanding the disease's pathogenesis.
Background: Senile osteoporosis (SOP) is an age-related metabolic bone disease that currently lacks specific therapeutic interventions. Thus, this study aimed to investigate the effect of Astragaloside IV (AS-IV) on macrophage senescence, bone marrow mesenchymal stem cell (BMSC) osteogenesis, and SOP progression.
Methods: A senescent macrophage model was established and treated with varying concentrations of AS-IV.