Publications by authors named "Wulong Lei"
Introduction: This study examined the impact of 5'-(N- ethylcarboxamido)adenosine (NECA) in the peripheral blood of healthy individuals, those with diabetes mellitus, diabetic retinopathy (DR), and C57BL/6 mice, both and .
Methods: Enzyme-linked immunosorbent assay (ELISA) and flow cytometry (FCM) were used to evaluate the effects of NECA on dendritic cells (DCs) and mouse bone marrow-derived dendritic cells (BMDCs) and the effects of NECA-treated DCs on Treg and Th17 cells. The effect of NECA on the Toll-like receptor (TLR) pathway in DCs was evaluated using polymerase chain reaction (PCR) and western blotting (WB).
Article Synopsis
- 5α-Hydroxycostic acid, derived from the plant Laggera alata, shows potential as a treatment for choroidal neovascularization (CNV) by inhibiting the formation and leakage of these abnormal blood vessels.* -
- The study utilized both in vitro and in vivo models to analyze the effects of 5α-Hydroxycostic acid on cell proliferation, migration, and tubule formation, highlighting its ability to improve cell adhesion by targeting specific signaling pathways.* -
- Results indicate that this compound effectively reduces vascular leakage and suggests that its mechanisms of action involve interference with the VEGF/VEGFR and Ang2/Tie2 pathways, making it a promising candidate for CNV therapy
Article Synopsis
- * Researchers have developed Angiopoietin1-anti CD105-PLGA nanoparticles (AAP NPs), which noninvasively target CNV, enhance drug delivery, and improve vascular stability while reducing leakage.
- * In animal studies, AAP NPs showed significant therapeutic effects in decreasing CNV leakage, offering a promising alternative for treating AMD without the complications of current methods.