Noninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been increasingly used to measure steroids in human saliva. We studied the performance of a conventional LC-MS/MS for measuring dehydroepiandrosterone (DHEA), testosterone and progesterone in human saliva. These three steroids were co-extracted by liquid-liquid extraction and derivatized.

Fluctuations in progesterone moderate the relationship between daily mood and alcohol use in young adult women.

Background: Research has demonstrated associations between hormonal fluctuations during the menstrual cycle and women's alcohol use. This association has been explained by mood changes that, for some women, accompany decreasing levels of progesterone during the menstrual cycle, particularly during the late luteal/premenstrual phase. The current study examined whether participants' daily ratings of mood interact with changing levels of progesterone to predict alcohol use.

Debiasing of gambling beliefs and behaviors using a digital gambling accelerator.

Problem gamblers tend to adhere to rigid rules about the chances of winning and are resistant to counterfactual information. To promote a more accurate understanding of the odds of scratch-off ticket gambling, we created a brief debiasing intervention consisting of a digital gambling accelerator program that offers demonstrations of the long-term outcomes of gambling. Using a sample of nontreatment seeking scratch-off lottery gamblers recruited from the community (42 subclinical and 45 probable pathological gamblers), we compared the accelerator intervention to brief motivational interviewing (MI) and a control condition.

Noninvasive determination of human cortisol and dehydroepiandrosterone sulfate using liquid chromatography-tandem mass spectrometry.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) for measurements of steroids in human saliva has garnered increased interest in the area of clinical psychoneuroendocrinological research. However, performance characteristics of LC-MS/MS methods for the analysis of steroids in saliva are limited. Human saliva samples were collected via passive drool.

Stress responding and stress-related changes in cue reactivity in heavy smokers, problem gamblers, and healthy controls.

Addictions, both substance and behavioral, have been conceptualized as involving similar biopsychosocial processes with different opportunistic expressions. A maladaptive stress response in combination with craving or urges to engage in the addictive behavior may be among the underlying factors common to behavioral and substance addictions. The current study compared the neuroendocrine (cortisol) and subjective responses to stress of gamblers and smokers to healthy controls.

Internalizing Risk Factors for College Students' Alcohol use: A Combined Person- and Variable-Centered Approach.

Background: Most studies that investigate internalizing problems (i.e., depression and anxiety symptoms) and alcohol use disorders use variable-centered approaches, losing important information about differences among individuals.

Distress tolerance and physiological reactivity to stress predict women's problematic alcohol use.

Research has shown that measures of reactivity to distress-including distress tolerance and physiological reactivity to stress-are dysregulated in women who misuse alcohol. These variables may interact and create a risk profile for young adult women, reflecting patterns of stress reactivity that confer a risk for alcohol misuse. The current study tested this hypothesis by examining the independent and interactive associations of subjective distress tolerance, behavioral distress tolerance, and physiological stress reactivity with women's alcohol misuse.

Effects of Acute Stress on Decision Making.

The study examined the effects of a social stressor (Trier Social Stress Test) on 24 male and 32 female college students' affective and physiological reactivity and their subsequent performance on a decision-making task (Iowa Gambling Task). The 56 participants were randomly assigned to a social stressor or a control condition. Compared to controls, participants in the stress condition responded with higher heart rates and skin conductance responses, reported more negative affect, and on the decision-making task made less advantageous choices.

Poor body image and alcohol use in women.

Two studies were conducted to examine the association between body image and alcohol use. Of interest was the extent to which alcohol outcome expectancies act as a moderator in this relationship, particularly in women. In Study 1, 421 college students (175 men, 246 women) provided self-report data on body image, social expressiveness expectancies, and average weekly alcohol use; the data were examined using a moderation model.

Treatment-seeking precipitators in problem gambling: analysis of data from a gambling helpline.

Although research on treatment precipitators for problem gambling is scarce, telephone surveys have consistently shown that financial and emotional problems resulting from problem gambling are the factors which recovered or active gamblers most frequently report as treatment precipitators. The present study sought to build on previous evidence by analyzing the demographic and gambling-related information provided by gamblers calling the helpline operated by the New Mexico Council on Problem Gambling and receiving a referral to private counseling. Specifically we examined the differences between the callers who initiated treatment with a private counselor after receiving the referral (n = 223), and those who were likewise referred to counseling but did not attend the first appointment (n = 231).

The relationship between parental alcohol use and college students' alcohol-related cognitions.

This study examined how parental and cognitive factors are structurally related to college students' intention to drink alcohol as well as possible gender differences in these relationships. Multiple-group comparison was used in structural equation modeling to assess data-to-model fit of the hypothesized model. Perceived parental alcohol use, positive expectancies, abstinence self-efficacy in social situations, and intent to drink alcohol were structurally modeled and examined in 714 college students based on self-report measures.

Problematic Internet use and other risky behaviors in college students: an application of problem-behavior theory.

Given the widespread use of the Internet, researchers have begun to examine the personal and social consequences associated with excessive online involvement. The present study examined college students' problematic Internet use (PIU) behaviors within the framework of Jessor and Jessor's (1977) problem-behavior theory. Its specific aim was to investigate the links between PIU with both internalizing (depression, social anxiety) and externalizing (substance use and other risky behaviors) problems.

The use of messages in altering risky gambling behavior in experienced gamblers.

The present study was an experimental analogue that examined the relationship between gambling-related irrational beliefs and risky gambling behavior. Eighty high-frequency gamblers were randomly assigned to four conditions and played a chance-based computer game in a laboratory setting. Depending on the condition, during the game a pop-up screen repeatedly displayed either accurate or inaccurate messages concerning the game, neutral messages, or no messages.

The effects of realistic reward and risk on simulated gambling behavior.

Laboratory studies on gambling may not represent an accurate analog of actual gambling behavior because they typically fail to model a meaningful level of risk and reward that is given in real-world settings. The current study sought to address this problem. One hundred and twenty college students were given the opportunity to bet valued experimental credits required for passing an introductory psychology course on the outcome of a videotaped horse race while their heart rate was monitored.

Male gamblers have significantly greater salivary cortisol before and after betting on a horse race, than do female gamblers.

Prevalence rates of gambling are influenced by gender. Among normative populations, hypothalamic-pituitary-adrenal (HPA) axis response to stress is affected by gender. However, pathological, compared to recreational, gamblers demonstrate perturbations in HPA activation in response to gambling stimuli.

Cue reactivity in active pathological, abstinent pathological, and regular gamblers.

Twenty-one treatment-seeking pathological gamblers, 21 pathological gamblers in recovery, and 21 recreational gamblers watched two video-taped exciting gambling scenarios and an exciting roller-coaster control scenario while their arousal (heart rate and subjective excitement) and urge to gamble were being measured. The gamblers did not differ significantly in cue-elicited heart rate elevations or excitement. However, the active pathological gamblers reported significantly greater urges to gamble across all cues compared to the abstinent pathological gamblers and, with marginal significance (p = 0.

Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder.

Sex differences in incidence and severity of some stress-related, neuropsychiatric disorders are often reported to favor men, suggesting that women may be more vulnerable to aberrant hypothalamic-pituitary-adrenal (HPA) axis responses to stress. In this review, we discuss several investigations that we, and others, have conducted assessing salivary cortisol as a measure of HPA function. We have examined basal cortisol among healthy men and women and also following acute exposure to stressors.

The co-occurrence of alcohol use and gambling activities in first-year college students.

Objective: Both alcohol use and gambling are behaviors that can be problematic for many college students; however, it is not clear whether the relationship between the 2 exists for students who have recently entered college.

Participants: The sample included 908 first-year college students who were surveyed in fall 2005, approximately 1 month after entering college.

Methods: Participants completed Web-based surveys on alcohol use and gambling behaviors.

Gambling pathology is associated with dampened cortisol response among men and women.

Pathological gambling has many similarities to pharmacological addiction. Notably, both pathological gambling and drug addiction are characterized by aberrations in hypothalamic-pituitary-adrenal (HPA) axis responding. As well, there are indications that gender differences may play a role in these processes.

The use of messages in altering risky gambling behavior in college students: an experimental analogue study.

This study examined the effects of messages on altering risky gambling behavior in college students. While playing a chance-based computerized game with play money, three groups of participants either viewed occasional accurate messages that correctly described the contingencies of the game, neutral messages unrelated to the contingencies, or no messages. Participants in the accurate message condition spent overall less money gambling, played fewer trials in the final phase of the game when all trials resulted in losses, and were more likely to quit the game while they still had money remaining in the bank.

7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells.

7beta-hydroxy-epiandrosterone (7beta-OH-EPIA) has been shown to be cytoprotective in various organs including the brain. It has also been shown that prostaglandin D2 (PGD2) and its spontaneous metabolite 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) are also cytoprotective. It is possible that these prostaglandins derived from circulating mononuclear cells may mediate the actions of 7beta-OH-EPIA.

The role of money in the excitement of gambling.

Many gamblers claim that gambling is intrinsically exciting, with money playing only a secondary role. To examine the effects of the expectancy of winning money, the authors randomly assigned 243 male college student gamblers to 1 of 6 experimental or 1 of 3 control conditions. Control participants either simply watched a videotaped horse race or they picked a horse, but without wagering; that horse later turned out to be either the winner of the race or the runner-up.