Publications by authors named "Wulei Hou"
Metastasis poses a huge obstacle to the survival of breast cancer patients. The microRNA miR-1205 acts as a tumor suppressor in various cancers, but its roles in breast cancer and metastasis remain unclear. To elucidate its function in breast cancer progression, we analyzed miR-1205 expression in human tumor samples and carried out a series of functional studies in in vitro and in vivo.
View Article and Find Full Text PDFCBX4 deletion promotes tumorigenesis under Kras background by inducing genomic instability.
Signal Transduct Target Ther
September 2023
Article Synopsis
- CBX4 is part of the Polycomb group proteins involved in various biological processes, but its deletion can have contrasting effects depending on the tissue type and disease context.
- This study shows that deleting CBX4 in lung adenocarcinoma (LUAD) with Kras mutations accelerates cancer cell growth and progression, with significant apoptosis occurring in the initial stages of cell transformation.
- Analysis revealed that CBX4 deletion leads to genomic instability and changes in key cellular pathways, linking low CBX4 expression to poorer patient outcomes in LUAD, highlighting its potential as a therapeutic target.
Hippo pathway is an evolutionarily conserved signaling pathway comprising a series of MST/LATS kinase complexes. Its key transcriptional coactivators YAP and TAZ regulate transcription factors such as TEAD family to direct gene expression. The regulation of Hippo pathway, especially the nuclear level change of YAP and TAZ, significantly influences the cell fate switching from proliferation to differentiation, regeneration, and postinjury repair.
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