Publications by authors named "Wujuan Zhu"
Article Synopsis
- Chemotherapy is a common yet problematic cancer treatment due to issues like poor drug solubility, stability, and drug resistance that lead to limited effectiveness and severe side effects.
- Researchers are exploring innovative combinations of therapies, focusing on targeted therapy, prodrug design, and drug delivery to create improved treatments, such as a self-assembled camptothecin (CPT) prodrug known as CPT-SS-FFEYp-Biotin.
- This prodrug enhances the therapeutic effects on tumor cells while minimizing harm to normal cells, demonstrating greater efficacy and safety, and suggesting potential for developing more prodrugs for effective cancer treatments in the future.
An uncontrolled immune response leads to many diseases; therefore, monitoring inflammation is crucial for the diagnosis of subsequent diseases, drug screening, and targeted therapy. Since the inflammatory response mainly occurs in macrophages, there is a need to develop more inflammatory probes with macrophage-targeting ability. Herein, we designed a macrophage-targeted and hydrogen-peroxide-activated fluorescent probe for real-time imaging of inflammation in vivo and a control probe without the macrophage-targeting part.
View Article and Find Full Text PDFLegumain has been identified as a target for diagnosis and treatment of associated cancers. Therefore, real-time imaging of legumain activity in vivo is helpful in diagnosing and evaluating therapeutic efficacy of associated cancers. Fluorescent/photoacoustic (FL/PA) dual-modal imaging developed rapidly because of its good sensitivity and spatial resolution.
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