Publications by authors named "Wuji Gao"

Many circular RNAs (circRNAs) are reported to be abnormally expressed during the progression of various tumors, and these circRNAs can be used as anti-tumor targets. Therefore, it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer (CRC). Here, we report that hsa_Circ_0000826 (Circ_0000826), a circRNA with significantly reduced expression level in CRC tissues, is associated with a poor prognosis in patients.

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Background: Glioma is a common malignant brain tumor. The purpose of this study was to investigate the role of the transcription factor SPI1 in glioma.

Methods: SPI1 expression in glioma was identified using qRT-PCR and Western blotting.

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Article Synopsis
  • Tumor cells primarily use aerobic glycolysis for energy, with hexokinase 2 (HK2) playing a crucial role, making it a potential target for cancer therapy.
  • In colorectal cancer, HK2 expression is significantly higher in tumor tissues compared to adjacent normal tissues, and its levels are linked to cancer progression and patient outcomes.
  • The HK2 inhibitor 3-Bromopyruvate (3-BP) effectively reduces colon cancer cell survival and induces apoptosis while also causing endoplasmic reticulum stress, suggesting that targeting both HK2 and stress responses could enhance cancer treatments.
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Colorectal cancer (CRC) is one of the most prevalent malignant tumors worldwide. Colon adenocarcinoma (COAD) is the most common pathological type of CRC and several biomarkers related to survival have been confirmed. Yet, the predictive effect of a single gene biomarker is not enough.

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Cancer immunotherapy works by stimulating and strengthening the body's anti-tumor immune response to eliminate cancer cells. Over the past few decades, immunotherapy has shown remarkable efficacy in the treatment of cancer, particularly the success of immune checkpoint blockade targeting CTLA-4, PD-1 and PDL1, which has led to a breakthrough in tumor immunotherapy. Tumor neoantigens, a new approach to tumor immunotherapy, include antigens produced by tumor viruses integrated into the genome and antigens produced by mutant proteins, which are abundantly expressed only in tumor cells and have strong immunogenicity and tumor heterogeneity.

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