Ethnoveterinary medicines in four districts of Jimma zone, Ethiopia: cross sectional survey for plant species and mode of use.

Background: Traditional medicines have been used for nearly 90% of livestock populations in Ethiopia where complimentary remedies are required to the modern health care system. All plants with pharmacological activity complimentarily prescribed as best choice against livestock diseases. A community based cross - sectional survey was conducted to investigate ethno-veterinary knowledge and practices of study area by purposive sampling techniques.

Anti-tuberculosis drug induced hepatotoxicity among TB/HIV co-infected patients at Jimma University Hospital, Ethiopia: nested case-control study.

Background: This study was carried out to determine the incidence and predictors of anti-tuberculosis drug induced hepatotoxicity among TB/HIV co-infected patients at Jimma University Hospital, Ethiopia.

Methods/principal Findings: A nested case-control study was conducted by reviewing charts of all TB/HIV co-infected patients who commenced anti-TB treatment from January 2008 to December 2011 at Jimma University Hospital. Patients who had developed hepatotoxicity after at least 5 days of standard doses of anti-TB drug therapy were labeled as "cases" and those without hepatotoxicity were "controls".

Determinants of glycemic control among insulin treated diabetic patients in Southwest Ethiopia: hospital based cross sectional study.

Background: Good glycemic control reduces the risk of diabetic complications. Despite this, achieving good glycemic control remains a challenge in diabetic patients. The objective of this study is to identify determinants of glycemic control among insulin treated diabetic patients at Jimma University Hospital, Southwest Ethiopia.

Prevalence and assessment of factors contributing to adverse drug reactions in wards of a tertiary care hospital, India.

Background: Adverse drug reactions account for the highest proportion among the causes of morbidity and mortality in clinical wards and are posing a considerable challenge. Hence, the objective of this study was to find out the prevalence of adverse drug reactions and the factors which contribute to their prevalence.

Methods: A prospective patient record review was carried out at a tertiary care hospital in North India from August 2010-May 2011.

In vivo evaluation of doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using DMBA-induced mammary carcinoma rat model and comparison with marketed LipoDox™.

Purpose: To evaluate in vivo doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using 7,12-dimethyl benz[α]anthracene (DMBA)-induced mammary carcinoma rat model compared to marketed formulation LipoDox™.

Methods: Sprague Dawley female rats with mean tumor volume of about 2 cm(3) were used for pharmacokinetics, biodistribution, antitumor efficacy and toxicity studies.

Results: This study demonstrates that PolyDoxSome has higher AUC (569 vs.

A systematic study on lyophilization process of polymersomes for long-term storage using doxorubicin-loaded (PEG)₃-PLA nanopolymersomes.

This study is focused on lyophilization process, physicochemical characterization and long-term storage stability studies of lyophilized doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes. Nanopolymersomes were prepared by nanoprecipitation method using (PEG)(3)-PLA copolymer and lyophilized in the presence of different lyoprotectants and evaluated for physicochemical properties. The lyophilized product was studied for long-term stability at 2-8 °C, 25 °C/65% RH and 40 °C/75% RH over predetermined periods and evaluated for changes in physicochemical properties.

Self assembling polymers as polymersomes for drug delivery.

Polymersomes are one of the most interesting and versatile architectures among various self assembled systems for drug delivery. The stability and ability to load both hydrophilic and hydrophobic molecules make them excellent candidates to use as drug delivery systems. They demand for certain physicochemical parameters; especially hydrophilic to hydrophobic block ratio of copolymer to form vesicular morphologies.

Doxorubicin-loaded (PEG)₃-PLA nanopolymersomes: effect of solvents and process parameters on formulation development and in vitro study.

This study is focused on the preparation of doxorubicin-loaded nanopolymersomes (PolyDoxSome) and assessment of the effects of various solvents and process variables on the size and drug loading during preparation of formulation. PolyDoxSome was prepared by nanoprecipitation method using amphiphilic (PEG)₃-PLA copolymer, and the formation of polymersomes was assessed by dynamic light scattering and optical and transmission electron microscopy and evaluated for in vitro release profile and in vitro cytotoxicity. A systematic investigation indicated that solvent composition, order of addition, aqueous phase, copolymer concentration, and external energy input have significant influence on size and dispersity of PolyDoxSome.