Neoadjuvant Immunotherapy With Ipilimumab Plus Nivolumab in Mismatch Repair Deficient/Microsatellite Instability-High Colorectal Cancer: A Preliminary Report of Case Series.

Background: Although ipilimumab plus nivolumab have significantly improved the survival of metastatic colorectal cancer (CRC) with mismatch repair deficient (dMMR) /microsatellite instability-high (MSI-H), the data on neoadjuvant setting is limited.

Patients And Methods: We enrolled 11 patients with advanced dMMR/MSI-H CRC. 10 patients were locally advanced and 1 was metastatic.

Bioaccessibility and risk assessment of cadmium from uncooked rice using an in vitro digestion model.

Cadmium (Cd)-contaminated rice is one of the most important sources of cadmium exposure in the general population from some Asian countries. This study was conducted to assess cadmium exposure from uncooked rice in rural mining areas based on the bioaccessible fraction of cadmium using an in vitro digestion model. The biotoxic effects of cadmium in uncooked rice from mining areas were much higher than those in the control area, based not only on their higher total concentration (52.

[Relationship between longevity and soil environment in Xiayi County, Henan Province, China].

Based on field investigation and laboratory analysis, exploration was done of distribution of macro and micro elements in the soils and distribution of longevity population in Xiayi County, Henan Province, China, and relationship between the spatial variation of the distribution of soil elements and the distribution of the longevity population. It was found that longevity population was distributed in a belt running across Xiayi county from northeast to southwest. In the northeast part, the longevity rate (over 95 years old) reached 187 per million and while in the northwest part, it was only 83.

[Determination of five trace elements (Pb, Cd, Se, As and Hg) in human whole blood by temperature-controllable wet digestion and ICP-MS technique].

A method for the determination of five trace elements, including Pb, Cd, Se, As and Hg concentrations in human whole blood by HNO3-H2O2 digestion under temperature-controllable condition and ICP-MS was described. Under the optimum experimental conditions and instrumental operation parameters, the limit of detection for the five elements were 2-40 ng x L(-1). The system had a good stability with RSDs of the determination of value repeated 3 times less than 3%.

Fluoride in drinking water, brick tea infusion and human urine in two counties in Inner Mongolia, China.

The objective of this study was to detect the fluoride level in the drinking water and the urine of habitants aged 16-55 years living in Inner Mongolia China. Furthermore, fluoride concentration of the brick tea infusion samples which were drunk by Mongolia herdsmen in everyday life living in SumuErga village of Ejin Horo Banner, Inner Mongolia China was also determined. A total of 117 participants (61 female and 56 male) were recruited from two counties for a cross-sectional study on health effects of chronic fluoride exposure from drinking water and drinking brick tea infusion.

[Lead uptake by plant in soil-plant system at lead-zinc deposit area of western Hunan province].

Contents of lead in several crops as well as its uptake and distribution by paddy in typical lead-zinc deposit area of western Hunan province were studied based on field systematic sampling and laboratory analysis. The average concentration of lead in rice, maize and soy bean in the deposit was 2.4, 1.

[Chemical speciation and pollution characteristics of soil mercury in mercury deposit area of Western Hunan-Eastern Guizhou province].

By the BCR extraction procedures and HG-ICP-AES technique, the chemical speciation and pollution characteristics of soil mercury in typical mercury deposit areas of Western Hunan-Eastern Guizhou province were studied. It was found that the concentrations of mercury in soils are dominated by residual form, followed by organic-sulfide form. Fe-Mn oxides and acid-exchangeable form are rather low.

[Determination of trace mercury and arsenic in human hair of polymetallic mining area by HG-ICP-AES].

In the present paper, a method for the determination of trace elements such as Hg and As in biological samples by HG-ICP-AES was presented. Under the optimum experimental conditions and instrumental operation parameters, both the RSDs of Hg and As with the method were below 3%, and the detection limits were 0.6 ng Hg x mL(-1) and 0.

[Determination of trace elements in drinking water of Kashin-Beck disease (KBD) affected and non-affected areas in Tibet by ICP-AES].

Trace elements (Cu, Zn, Fe, Ca, Mg, Mn, Al, K, Ba, P, Sr, Cd, V, Cr, Ni, Pb and Co) concentrations in the drinking water of KBD-affected and non-affected areas were measured using ICP-AES. The RSD of this method was between 0.80% and 2.

Arsenic accumulation by ferns: a field survey in southern China.

The objective of this study reported here was to characterize arsenic (As) accumulation by Pteris ferns by comparing 3 of the ferns of this genus with each other as well as with four non-Pteris ferns growing on seven sites in southern China with different As levels. A total of 112 samples, including 78 Pteris vittata, 13 P. cretica, 3 P.

[Study advance on haloacetic acids in drinking water].

Haloacetic acids (HAAs) in drinking water have attracted more and more attention of researchers due to their higher potential combination of chlorine, their carcinogenic and mutagenic effects and higher carcinogenic. The formation mechanism, analytical methods, the effects of many factors on HAAs formation such as precursor types, chlorine doses, pH, temperature, bromide, reaction time and seasonal change, toxicological character and the minimizing technology of HAAs in resent studies about HAAs are discussed in details in this paper. Further researches are still needed to clarify the formation mechanism of HAAs and find a feasible minimizing technology.

[Environmental quality of soil polluted by mercury and lead in polymetallic deposit areas of western Hunan Province].

The environmental quality of soil polluted by mercury and lead in typical polymetallic deposit areas of western Hunan province and its natural and human causes were studied. It was found that western Hunan province is a high regional geochemical abnormal region on mercury and lead. The concentrations of mercury and lead in soils in mercury deposit areas were 1 315 and 3.

[Determination of nine life elements in brick tea by ICP-AES].

ICP-AES was used for the direct determination of nine life elements (Ca, Mg, K, Al, P, Cu, Zn, Fe and Mn) in brick tea. The RSDs of the method were between 2.11% and 8.

[Regularity of flourine release from fluorine-rich coal combustion in the fluorine poisoning area].

Laboratory experiments and in situ measurements inside farmer's houses indicate that the fluorine concentration of indoor air was positively related with the fluorine content in the consumed coal (R = 0.612, P<0.01), but fluorine content in the coal had no effect on the release rate of coal fluorine under the usual combustion temperature of about 1000 degrees C.

[The application of GIS to environmental health informatics].

In order to improve the management of environment and human health, this paper presented the new concept of human health, and developed the environmental health informatics. Its features, structure and major approach for application have been summarized. The future development of environmental health informatics was discussed.