Three stilbenes from pigeon pea with promising anti-methicillin-resistant Staphylococcus aureus biofilm formation activity.

Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of these stilbenes against Staphylococcus aureus and even methicillin-resistant Staphylococcus aureus (MRSA) and test the possibility of inhibiting biofilm formation. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of these stilbenes were evaluated.

Four new stilbenes and one new flavonoid with potential antibacterial and anti-SARS-CoV-2 activity from Cajanus cajan.

Four new stilbenes (1-4) and one new flavonoid (5), named cajanines D-H, together with three known stilbenes (6-8) were isolated from the leaves of Cajanus cajan (L.) Millsp. (pigeon pea).

The sesquiterpenes with the COVID-19 M inhibitory activity from the L.

The extract of the whole plant of L. yielded four new sesquiterpenes including a novel skeleton (claroguaiane A, ), two guaianolides (claroguaianes B-C, ), and one eudesmanolide (claroeudesmane A, ), together with three known sesquiterpenoids (). The structures of the new compounds were elucidated by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data.

Four new eudesmane-type and one new eremophilane-type sesquiterpenes from the whole plant of Carpesium abrotanoides L.

The extract of the whole plant of Carpesium abrotanoides L. yielded five new sesquiterpenes including four eudesmanes (1-4) and one eremophilane (5). The new compounds were characterized by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data.

Three new glycosides from the stems of R. Br.

Two new phenolic glycosides ( and ), one known analogue (), along with a new diterpene glucoside () were obtained from ethanolic extract of the stems of R. Br. The structures of these isolated compounds were identified by extensive analysis of HRESIMS and NMR spectroscopic data.

Two new withanolides from the whole plants of .

Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, and ), along with twelve known withanolides (-), were purified and identified from L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7.

Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis.

has been recorded as a folk medicine traditionally used for treatment of a variety of symptoms. However, the phytochemical and pharmacological investigations of this plant are still scarce. A novel phenolic glycoside named Euryachincoside (ECS) was isolated by chromatographic separation from and its chemical structure was identified by analysis of HRMS and NMR data.

Peruranolides A-D, four new withanolides with potential antibacterial and cytotoxic activity from L.

Background: Many drugs for anti-tumour have been developed, nevertheless, seeking new anticancer drug is the focus of ongoing investigation. Withanolides have been reported to possess potent antiproliferative activity. Literature findings revealed that a diversity of withanolides were obtained from , however, the antitumor activity of these bioactive compounds is still unclear.

Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.

Dicarabrols B and C (1 and 2), two new carabrane sesquiterpenoid dimers, along with one new carabrane sesquiterpenoid (3) were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data, and time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. Dicarabrol B possesses a novel C skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties, while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule.

A Review on the Phytochemical and Pharmacological Properties of Rosa laevigata: A Medicinal and Edible Plant.

Rosa laevigata Michx., a medicinal and edible plant in China, has exerted a variety of medicinal values and health benefits. This present review aims to achieve a comprehensive and up-to-date investigation in the phytochemistry and pharmacology of R.

Rosanortriterpenes A-B, Two Promising Agents from var. , Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models.

Rosanortriterpenes A-B (RTA and RTB), two nortriterpenoids, are characteristic constituents in the fruits of var. . However, pharmacological studies on these compounds are still scarce.

Two new 7,20-epoxy--kaurane diterpenoids from the aerial parts of .

Two new compounds ( and ), belonging to C-20 oxygenated -kauranes-type diterpenoids, were identified from the aerial parts of . Their structures were elucidated by extensive analysis of HRESI-MS and NMR spectroscopic data. Both these two compounds possess a common 7,20-epoxy--kauranes skeleton with a hydroxyl group rarely occurring at C-13.

Three new pterocarpans from the aerial parts of .

Three new pterocarpans, named abrusprecatins A-C (), along with three known ones, namely medicarpin (), maackiain (), and 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan () were isolated from the aerial parts of . The structures of these compounds were established by extensive analysis of mass spectrometric data, 1 D and 2 D NMR spectroscopic data. In addition, the absolute configurations were determined by a combination of single crystal X-ray diffraction analysis and circular dichroism spectroscopy.

Rosanortriterpenes A-B, two new nortriterpenes from the fruits of var. .

One new oleanane-type nortriterpene, rosanortriterpene A (), and one new ursane-type nortriterpene, rosanortriterpene B (), were isolated from the fruits of var. . The structures of - were fully characterised on the basis of extensive spectroscopic analysis, including IR, HRESIMS, as well as 1D and 2D NMR spectral data (HSQC, H-H COSY, and HMBC).

Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from .

A phytochemical investigation on the leaves of resulted in the isolation of two unusual compounds, callistemonols A () and B (). Callistemonol A () possesses a novel skeleton of a furan ring fusing both an α,β-triketone and a phloroglucinol unit, while callistemonol B () is an acylphloroglucinol derivative featuring two methyl substituents on a five-membered ring and an isovaleryl side chain. Their structures were fully characterized on the basis of extensive spectroscopic analysis, including 1D and 2D NMR parameters, as well as the IR and HRESIMS data.

The enhanced photo-thermal therapy of Surface improved photoactive cadmium sulfide (CdS) quantum dots entrenched graphene oxide nanoflakes in tumor treatment.

Cancer is one of the death causing disease is always being a public health concern due to its rapid increase in the world population. Hyperthermal therapy is an anticancer treatment mutually given with chemotherapy. In the present study, CdS/rGO nanocomposites were synthesized using simple and scalable solvothermal method and applied as an efficient material in anticancer treatment.

Two new ent-kaurane diterpenes from the stems of Eurya chinensis.

Two new ent-kaurane diterpenes (1-2), together with five known analogs, were isolated from the stems of Eurya chinensis. The structures of new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound 3 exhibited noticeable anti-inflammatory activity as denoted by inhibiting LPS-induced nitric oxide (NO) production in RAW264.

Three new kavalactone dimers from Piper methysticum (kava).

Three new dimeric kavalactones, designated as diyangonins A-C (1-3), along with two known analogs were isolated from the roots of Piper methysticum. Their structures were elucidated by means of extensive analysis of their 1D, 2D NMR, and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units in head-to-tail or head-to-head mode.

A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R.Br.

One new ent-kaurane diterpene derivative (1), along with four known diterpenes, was isolated from the stems of Eurya chinensis R.Br. The structure of the new compound was established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data.

Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava).

Three new kavalactone dimers, designated as yangonindimers A-C (1-3), along with one known analogue were isolated from the roots of Piper methysticum. Their structures were elucidated via extensive analysis of their 1D, 2D NMR and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units.

Callviminols A-E, new terpenoid-conjugated phloroglucinols from the leaves of Callistemon viminalis.

Callviminols A-E (1-5), five rare phloroglucinols bearing a framework embodying a hexahydrodibenzo[b,d]furan or 2-phenylcyclohexanol nucleus derived from a phloroglucinol-monoterpene adduct, were isolated from the leaves of Callistemon viminalis. Their structures were established via extensive spectroscopic measurements, with the absolute configuration of 5 determined by electronic circular dichroism (ECD) calculations. The plausible biogenetic pathway suggested that a unique oxidative radical addition and classic cationic cyclization were key biosynthetic steps.

Acylphloroglucinols from the leaves of Callistemon viminalis.

A phytochemical study on the leaves of Callistemon viminalis, a widely distributed ornamental and medicinal plant of agricultural importance in China, resulted in the isolation of eleven acylphloroglucinols, including six new ones named callistenones F-K (1-6), as well as five known congeners. Their structures were fully characterized using spectral data interpretation for the new structures and compared to published data for the known ones. All the isolated compounds were evaluated for in vitro antimicrobial activity and growth inhibitory activity against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2).

Performance of tetramethoxyphenyl porphyrin cobalt(II) (CoTMPP) based stainless steel cathode in the electricigenic permeable reactive barrier for groundwater organic contamination remediation.

An electricigenic permeable reactive barrier (EPRB) technology was brought forward for remediation of organic-contaminated groundwater, with a benefit that it overcame the limitations of electron acceptor addition in other groundwater remediation methods. To investigate performances of constructions and materials used in EPRB system, several kinds of reactors were designed and prepared in laboratory. Stainless steel wires, a kind of nontoxic, inexpensive and conductive material, were used as basic material of electrode.