Publications by authors named "Wu-Yi You"
Background: The utility of pre- and post-operative alpha-fetoprotein (AFP) and des-gamma (γ)-carboxy prothrombin (DCP) expression patterns and their dynamic changes as predictors of the outcome of hepatic resection for hepatocellular carcinoma (HCC) has yet to be well elucidated.
Methods: From a multicenter database, AFP and DCP data during the week prior to surgery and the first post-discharge outpatient visit (within 1-2 months after surgery) were collected from patients with HCC who underwent hepatectomy. AFP-DCP expression patterns were categorized according to the number of positive tumor markers (AFP ≥ 20ng/mL, DCP ≥ 40mAU/mL), including double-negative, single-positive, and double-positive.
Article Synopsis
- The study evaluates the safety and outcomes of salvage liver resection in patients with initially unresectable hepatocellular carcinoma (HCC) made operable through treatments like TACE, TKIs, and anti-PD-1 antibodies.
- A total of 83 patients were reviewed, revealing a perioperative complication rate of 48.2% and a median recurrence-free survival (RFS) of 25.4 months, with significant factors like pathological complete response influencing outcomes.
- The findings suggest that salvage liver resection could be a viable treatment option for selected HCC patients with promising survival rates post-operation.