Preimplantation genetic testing as a preventive strategy for the transmission of mitochondrial DNA disorders.

Mitochondrial diseases are distinct types of metabolic and/or neurologic abnormalities that occur as a consequence of dysfunction in oxidative phosphorylation, affecting several systems in the body. There is no effective treatment modality for mitochondrial disorders so far, emphasizing the clinical significance of preventing the inheritance of these disorders. Various reproductive options are available to reduce the probability of inheriting mitochondrial disorders, including fertilization (IVF) using donated oocytes, preimplantation genetic testing (PGT), and prenatal diagnosis (PND), among which PGT not only makes it possible for families to have genetically-owned children but also PGT has the advantage that couples do not have to decide to terminate the pregnancy if a mutation is detected in the fetus.

Molecular mechanism of Decoction in treating chronic kidney disease based on network pharmacology.

There is a serious worldwide health problem caused by chronic kidney disease (CKD), yet there are few viable therapies. Therapeutic promise in the treatment of chronic kidney disease (CKD) has been shown by the use of the traditional Chinese herbal compound Decoction (SYD). However, the chemical processes through which SYD exerts its effects are still unknown.

The complete mitochondrial genome of Decne. (Asteraceae, Falc.).

The complete mitochondrial genome of was sequenced for the first time. The mitochondrial genome length was 320,439 bp, with 45.05% GC contents.

The complete mitochondrial genome of Rchb. (Ranales, Ranunculaceae).

Rchb. is a medicinal plant in the Ranunculaceae family. In this study, we report the first complete mitochondrial genome of .

The complete mitochondrial genome of Fisch. (Fabales, Leguminosae).

The complete mitochondrial genome of an important medicinal plant Fisch. is reported for the first time. The mitochondrial genome sequence of was 463,869 bp in length and had a GC content of 45.

[Cloning, expression and bioinformatics analysis of pyruvate dehydrogenase of Echinococcus granulosus].

Objective: To clone and express Echinococcus granulosus pyruvate dehydrogenase (EgPDH) gene and analyze EgPDH protein with bioinformatics tools and online database.

Methods: The total RNAs of E. granulosus was extracted and reversely transcribed into cDNA.