M2 macrophages secrete CCL20 to regulate iron metabolism and promote daunorubicin resistance in AML cells.

Chemotherapy resistance is a significant clinical challenge in the treatment of leukemia. M2 macrophages have been identified as key contributors to the development of chemotherapy resistance in cancer, yet the precise mechanisms by which macrophages regulate this resistance remain elusive. Our study has identified CCL20 as a pivotal factor in the promotion of chemoresistance in AML cells by M2 macrophages.

FMRFamide G protein-coupled receptors (GPCR) in the cuttlefish Sepiella japonica: Identification, characterization and expression profile.

FMRFamide is a ubiquitous neuromodulator in the animal kingdom. Once FMRFamide or similar neuropeptides bind to their G protein-coupled receptors (GPCR), a series of signal transduction events are triggered, thereby mediating various physiological effects. FMRFamide had been reported to be involved in the regulation of sexual maturation in Sepiella japonica.

A Na channel receptor of FMRFamide in the cephalopod Sepiella japonica: Identification, characterisation, and expression profiling during different stages of gonadal development.

FMRFamide, a member of the neuropeptide family, is involved in numerous physiological processes. FMRFamide-activated sodium channels (FaNaCs) are a family of non-voltage-gated, amiloride-sensitive, Na-selective channels triggered by the neuropeptide FMRFamide. In the present study, the full-length cDNA of the FaNaC receptor of Sepiella japonica (SjFaNaC) was cloned.

Fishery-based adaption to climate change: the case of migratory species flathead grey mullet ( L.) in Taiwan Strait, Northwestern Pacific.

The flathead gray mullet (.) is a cosmopolitan fish that lives in warm and temperate zones over 42°N-42°S. It is a key fish species for industrial fishing off coastal Taiwan.

Effects of antiseizure medications on alternative psychosis and strategies for their application.

Forced normalization (FN) is a unique phenomenon that is often seen in the treatment of epilepsy. FN is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control; the occurrence of FN seriously affects patients' quality of life. The causes of FN include antiseizure medications (ASMs), epilepsy surgery and vagus nerve stimulation, with ASMs being the most common cause.

Estimation of trapezoidal-shaped overlapping nuclear pulse parameters based on a deep learning CNN-LSTM model.

The Long Short-Term Memory neural network (LSTM) has excellent learning ability for the time series of the nuclear pulse signal. It can accurately estimate the parameters (such as amplitude, time constant, etc.) of the digitally shaped nuclear pulse signal (especially the overlapping pulse signal).

Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics.

Objective: To investigate the pharmacokinetic characteristics of 17 bioactive components including ginsenoside Rg1, Rb1, Rd, berberine, epiberberine, jatrorrhizine, palmatine, columbamine, coptisine, evodiamine, dehydroevodiamine, rutaecarpine, limonin, hyperin, curcumin, demethoxycurcumin and bisdemethoxycurcumin in rat plasma after oral administration of Xintiantai I extract powder (XI) and Xintiantai I without guide drug borneol extract powder (XI without borneol), and study the compatibility effects of guide drug borneol on the pharmacokinetics.

Methods: A UHPLC-MS/MS method was established and fully validated for the comparative pharmacokinetics of 17 bioactive components. The pharmacokinetics parameters of 17 bioactive components after oral administration of XI and XI without borneol were calculated by the software of DAS 3.

Computational study of the effects of arterial bifurcation on the temperature distribution during cryosurgery.

Background: Thermally significant blood flows into locally cooled diseased tissues and warm them during cryosurgery so that the iceball is often hard to cover the whole diseased volume. This paper is aimed at investigating the effects of large arterial bifurcation on the temperature distribution during cryosurgery through simulation method.

Methods: A parametric geometry model is introduced to construct a close-to-real arterial bifurcation.

[Present situation and prospects of acupuncture and moxibustion in United Kingdom].

The present paper reviews the development courses of acupuncture and moxibustion and gives an introduction to the present situation, education and legislation of acupuncture and moxibustion in United Kingdom. Acupuncture and moxibustion have been developed in United Kingdom since 1960s, the London College of TCM was established by Beijing University of Chinese Medicine join forced with Acu-medic Foundation in 1993, and so far, acupuncture has been taught as an undergraduate program in four United Kingdom universities. Since 2002, the British government and Ministry of Health have begun on the legislation of Chinese Medicine and acupuncture and moxibustion, the lawmaking group of Ministry of Health in British submitted a bill about the legislation of acupuncture and herbal medicine as well as Chinese Medicine to the British government in 2008.

[Relationship between measurements of tidal volume and thoracic inflating volume by pressure plethysmography in mice].

Objective: To evaluate the accordance of tidal volume (TV) with thoracic inflating volume (TIV) measured by pressure whole-body or double-chamber plethysmography in mice.

Methods: TV and TIV by double-chamber plethysmography were simultaneously measured in 6 mice with spontaneous respiratory frequencies 90 - 120/min; TV and TIV by whole-body plethysmography were measured in 8 paralyzed mice ventilated by fixed frequency.

Result: TIV value by double-chamber plethysmography was significantly higher than TV [(0.

Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE.

Objective: Acute pulmonary thromboembolism (PTE) is a serious high mortality pulmonary vascular disease whose effective treatment decreases morbidity and mortality. To determine if low-molecular-weight-heparin (LMWH) is clinically as efficient and safe as unfractionated heparin (UH) in patients with diagnosis of acute non-massive PTE, our study compares the efficacy, adverse effects and costs of LMWH and UH.

Methods: One hundred and fourteen patients with non-massive acute PTE were randomly divided into LMWH (nadroparin calcium) and UH groups.

[Pulmonary cryptococcosis: analysis of nine cases].

Objective: To investigate the diagnosis and treatment of pulmonary cryptococcosis.

Methods: A total of 9 cases of pulmonary cryptococcosis, diagnosed at Sir Run Run Shaw Hospital of Zhejiang University from January 2002 to August 2004, identified by pathological examinations, were retrospectively studied.

Results: The patients consisted of 7 males and 2 females aged from 28 to 69 years.

[Large-volume whole lung lavage in the treatment of severe pulmonary alveolar proteinosis].

Objective: To evaluate the efficacy and safety of large-volume whole lung lavage in the treatment of severe pulmonary alveolar proteinosis (PAP).

Methods: Five severe PAP patients underwent large-volume whole lung lavage under general anaesthesia using a double lumen endotracheal tube. Suction was used for returning fluid.